| Tne effets of anti-inflammatory ageets on bloed-aqueous-barrier in experimental uveitis. |
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Sung Do Park, Kwon Ho Lee, Kyoung Hwan Shin |
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Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea. |
| 각종항염제가 (各種抗炎劑) 포도막염때의 (葡萄膜炎) 혈관투과성에 (血管透過性) 미치는 영향 (影響) |
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윤원식(Won Sik Yoon),이권호(Kwon Ho Lee),박성도(Sung Do Park),신경환(Kyung Hwan Shin) |
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| Abstract |
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The purpose of this paper is to study the effects of anti-inflammatory agents on the blood-aqueous-berrier in experimentally induced uveitis. 10% solution of sodium fluorescein was injection intravenously in the ear vein of rabbits (0.25 ml/kg) and fluorescein curve was drawn after the method of Amsler and Huber. Experimental uveitis was induced by the injection of 0.2 ml of human serwn into the vitreous body. After uveitis had been induced. three kinds of anti-inflammatory agents-Prednisolone, Benzyron and Methotrexate-were Biven oralIy. In control animals in which no uveitis was induced, no changes in fluorescein curve were demonstrated before and after the administrations of drugs. In animals with uveitis, maked increases of the blood-aqueous barrier were noted. When Benoyron and Prednisolone were given to these animals, normaliration of the fluorescein curves were demonstrated. Methotrexate had no effects on the fluorescein curves in uveitis animals, showing no improvements in the permeability of uveal vessela. This ineffectiveness seemed to be due to the resistance of rabbits to methotrexate. |
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