Effects of 5-Fluorouracil on Delayed Adjustment in Experimental Strabismus Surgery.

Jeon, Woong Chan; Oh, Se Oh

Original Article

Journal of the Korean Ophthalmological Society 1996;37(11):1925-1930.
Published online November 1, 1996.

Effects of 5-Fluorouracil on Delayed Adjustment in Experimental Strabismus Surgery.

Woong Chan Jeon, Se Oh Oh

Department of Ophthalmology, Collage of Medicine, Chungbuk National University, Chunju, Korea.

실험적 사시 수술에서 5-FU가 지연조정에 미치는 효과

전웅찬(Woong Chan Jeon),오세오(Se Oh Oh)

Abstract

Adjustable sutures increased the rate of success with a single procedure, but sometimes fails because of changes in the angle of deviation which develops a few days after surgery. Therefore, the delayed adjustment was attempted;however, the postoperative adhesion following strabismus surgery make delayed adjustment impossible. We studied 45 eyes of 25 rabbits; adjustable strabismus surgery underwent a hang-back technique in the superior rectus muscle. In experimental group, a sponge was soaked in 5-Fluorouracil, and the sponge was placed between the conjunctiva and the sclera for 5 minutes during the operation. We studied the possible time of delayed adjustment and estimated the minimal forces required for the adjustment. The experimental group A (5-Fluorouracil, 50mg/ml) allowed for a 6 day delayed adjustment after surgery, control group allowed for a 2 day delayed adjustment after surgery. These results suggest that 5-Fluorouracil may valuable resource to delayed adjustment strabismus surgery by reduce postoperative adhesion.

Key Words: Adjustable strabismus surgery;Delayed adjustment;Postoperative adhesion;5-fluorouracil