Apoptosis in Experimental Autoimmune Uveitis.

Yu, Hyeong Gon; Lee, Wang Jae; Shin, Dong Hoon; Yu, Young Suk; Chung, Hum

Original Article

Journal of the Korean Ophthalmological Society 2002;43(3):608-614.
Published online March 1, 2002.

Apoptosis in Experimental Autoimmune Uveitis.

Hyeong Gon Yu, Wang Jae Lee, Dong Hoon Shin, Young Suk Yu, Hum Chung

¹Department of Ophthalmology, Seoul National University, College of Medicine, Korea.
²Seoul Artificial Eye Center Clinical Research Institute Seoul National University Hospital, Korea. chungh@snu.ac.kr
³Department of Anatomy, Seoul National University College of Medicine, Korea.
⁴Department of Anatomy, Dankook University College of Medicine, Korea.

실험적 자가면역 포도막염에서 FasL의 발현

유형곤 ( Hyeong Gon Yu ) , 이왕재 ( Wang Jae Lee ) , 신동훈 ( Dong Hoon Shin ) , 유영석 ( Young Suk Yu ) , 정흠 ( Hum Chung )

Abstract

PURPOSE
Fas ligand is known to play a key role in intraocular inflammation. We investigated the change of the expression of Fas ligand in the eye with experimental melanin-induced uveitis (EMIU). METHODS: EMIU was induced in 16 Lewis rats after immunization with melanin-associated antigen. Immunohistochemistry, in situ hybridization, and Western blot for Fas ligand were performed serially after immunization. RESULTS: The expression of Fas ligand was higher in the inflammatory eyes at cornea, iris, ciliary body, choroids and retina compared with control eyes. The expression of FasL remained elevated ever at 30 days after immunization in comparison with control eyes even though the inflammation of the eyes had subsided. CONCLUSIONS: These results suggest that the spontaneous regression of intraocular inflammation may be mediated by Fas ligand in EMIU.

Key Words: Experimental uveitis;Fas ligand