J Korean Ophthalmol Soc > Volume 59(11); 2018 > Article
Journal of the Korean Ophthalmological Society 2018;59(11):1024-1029.
DOI: https://doi.org/10.3341/jkos.2018.59.11.1024    Published online November 15, 2018.
Analysis of 25-Hydroxy Vitamin D in the Aqueous Humor of Age-related Macular Degeneration Patients.
Won Seok Song, Won Tae Yoon, Yong Kyu Kim, Sung Pyo Park
1Department of Ophthalmology, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea. eyepyo@gmail.com
2Goseong Public Health Center, Goseong, Korea.
습성 연령관련황반변성 환자에서 안구 방수 내 비타민 D 분석
한림대학교 강동성심병원 안과학교실1, 고성군 보건소2
Correspondence:  Sung Pyo Park,
Email: eyepyo@gmail.com
Received: 5 July 2018   • Revised: 20 August 2018   • Accepted: 22 October 2018
We examined aqueous humor levels of 25-hydroxyvitamin D (vitamin D) in patients with age-related macular degeneration to investigate possible relationships between aqueous humor vitamin D levels and clinical manifestations. METHODS: Patients > 50 years of age, 52 eyes of 34 patients with age-related macular degeneration, and 23 eyes of 17 patients treated with cataract surgery without retinal disease, were examined for aqueous humor vitamin D levels and compared. The experimental group was divided into two groups according to the median value of aqueous humor vitamin D levels. We compared the clinical manifestations of macular degeneration in both groups and identified relationships between aqueous humor vitamin D levels and clinical features. RESULTS: Vitamin D levels in the aqueous humor were significantly lower in the experimental group than in the control group (experimental, 10.03 ± 10.1 ng/mL vs. control group, 40.8 ± 16.4 ng/mL; p < 0.001). Patients with high vitamin D levels in the macular degeneration group had a higher percentage of fibrovascular pigment epithelial detachments than those in the low grade group (high grade group, 65% vs. low grade group, 27%; p = 0.003). Multiple linear regression analysis showed a significant correlation between vitamin D levels and the total number of anti-vascular endothelial growth factor intravitreal injections within 6 months (standardize coefficient, β = −0.336). CONCLUSIONS: Patients with wet age-related macular degeneration had significantly lower vitamin D levels in the aqueous humor compared to control group subjects of similar ages. However, in patients with macular degeneration, low vitamin D levels were associated with a greater number of intravitreal injections, while higher levels of vitamin D may lead to more advanced forms of fibrovascular retinal pigment epithelium and related low vision. These relationships were not always constant, so further studies on the relationships between local vitamin D levels and ocular disorders are needed.
Key Words: Age-related macular degeneration;Aqueous humor;Vitamin D

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