J Korean Ophthalmol Soc > Volume 58(7); 2017 > Article
Journal of the Korean Ophthalmological Society 2017;58(7):852-856.
DOI: https://doi.org/10.3341/jkos.2017.58.7.852    Published online July 15, 2017.
A Typical Case of IgG4-related Ophthalmic Disease Satisfying Diagnostic Criteria.
Sae Rom Chung, Tae Eun Lee, In Cheon You, Nam Chun Cho, Ho Sung Park, Min Ahn
1Department of Ophthalmology, Chonbuk National University Medical School, Jeonju, Korea. ahnmin@jbnu.ac.kr
2Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, Korea.
3Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Korea.
4Department of Pathology, Chonbuk National University Medical School, Jeonju, Korea.
면역글로불린G4관련안질환의 진단적 기준을 만족하는 전형적인 증례 1예
정새롬1⋅이태은1⋅유인천1,2,3⋅조남천1,2,3⋅박호성2,3,4⋅안 민1,2,3
전북대학교 의학전문대학원 안과학교실1, 전북대학교 임상의학연구소2, 전북대학교병원 의생명연구원3, 전북대학교 의학전문대학원 병리학교실4
Correspondence:  Min Ahn,
Email: ahnmin@jbnu.ac.kr
Received: 13 October 2016   • Revised: 6 December 2016   • Accepted: 17 June 2017
In the present study, a case of IgG4-related ophthalmic disease which met the 2015 IgG4-related ophthalmic disease diagnostic criteria is reported and literature review performed. CASE SUMMARY: A 51-year-old female presented with both upper eyelid swelling, redness, and a palpable mass. Eye movements were normal and exophthalmos was not observed. Facial computed tomography showed both lacrimal gland hypertrophy. The patient underwent left anterior orbitotomy with incisional biopsy. Immunostained biopsy showed the ratio of IgG4+ to IgG+ cells was 50% and the mean number of IgG4-positive plasma cells was approximately 150 per high-power field. Hematological examination showed elevated serum IgG4 concentrations of 6,930 mg/dL, however, other organs were not involved. The patient satisfied the diagnostic criteria for IgG4-related ophthalmic disease. The patient was given an oral steroid and immunosuppressant and the symptoms improved. CONCLUSIONS: IgG4-related ophthalmic disease is currently receiving increased attention. The authors of the present study report a case of IgG4-related ophthalmic disease which met the 2015 IgG4-related ophthalmic disease diagnostic criteria.
Key Words: Eyelid;IgG4-related disease;IgG4-related ophthalmic disease;Lacrimal gland

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