A Case of IgG4-Related Sclerosing Disease Involving the Optic Nerve.

Cho, Hyung Seok; Choi, Jung Yeol; Yum, Jung Hoon

doi:2012.53.12.1879

J Korean Ophthalmol Soc > Volume 53(12); 2012 > Article

Case Report

Journal of the Korean Ophthalmological Society 2012;53(12):1879-1884.
DOI: https://doi.org/10.3341/jkos.2012.53.12.1879 Published online December 15, 2012.

A Case of IgG4-Related Sclerosing Disease Involving the Optic Nerve.

Hyung Seok Cho, Jung Yeol Choi, Jung Hoon Yum

Department of Ophthalmology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. yumra-med@hanmail.net

시신경을 침범한 IgG4 연관 경화성 질환 1예

조형석⋅최정열⋅염정훈

Department of Ophthalmology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea

Abstract

PURPOSE
To report a case of IgG4-related sclerosing dacryoadenitis masquerading for a long period as a. CASE SUMMARY: A 59-year-old man with visual acuity loss and proptosis in the left eye was referred to our hospital. Ten years prior, the patient was diagnosed with lymphoma and underwent chemotherapy at another hospital. However, the patient spontaneously stopped treatment and took steroids for the relief of periorbital swelling. Magnetic resonance imaging revealed diffuse infiltrative lesions involving both optic nerves and extraocular muscles. Incisional biopsies of the lacrimal gland's posterior side and the lateral rectus muscle's lateral side were performed. Staining for IgG4 via immunochemistry showed infiltration of IgG4-positive lymphoplasmacytic cells. Under the diagnosis of IgG4-related sclerosing disease, the patient underwent high-dose steroid pulse therapy.

Key Words: IgG4-related sclerosing disease;Mikulicz disease;Orbital inflammatory disease