Tear Meniscus Evaluation Using Optical Coherence Tomography in Dry Eye Patients.

Jung, Na Yeon; Baek, Ji Won; Shin, Seong Joo; Chung, Sung Kun

doi:2015.56.3.323

J Korean Ophthalmol Soc > Volume 56(3); 2015 > Article

Original Article

Journal of the Korean Ophthalmological Society 2015;56(3):323-330.
DOI: https://doi.org/10.3341/jkos.2015.56.3.323 Published online March 15, 2015.

Tear Meniscus Evaluation Using Optical Coherence Tomography in Dry Eye Patients.

Na Yeon Jung, Ji Won Baek, Seong Joo Shin, Sung Kun Chung

¹Department of Ophthalmology, Sahmyook Medical Center, Seoul, Korea.
²Department of Ophthalmology and Visual Science, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. eyedoc@catholic.ac.kr

건성안 환자에서 빛간섭단층촬영을 이용한 눈물띠 분석

정나연¹⋅백지원²⋅신승주¹⋅정성근²

삼육서울병원 안과¹, 가톨릭대학교 의과대학 성바오로병원 안과 및 시과학교실²

Abstract

PURPOSE
To evaluate the tear meniscus in aqueous tear-deficient dry eye patients using Fourier-domain optical coherence tomography (FD-OCT) and to investigate the clinical usefulness of tear meniscus values. METHODS: The present study included 79 aqueous tear-deficient dry eyes and 50 normal eyes. Tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA) were imaged using FD-OCT and measured with computer calipers. Schirmer's test, tear break-up time, and corneal fluorescein staining were also performed and the correlations between the tests were analyzed. Additionally, the diagnostic power of tear meniscus values was compared using area under the receiver operating characteristic curve (AUROC). RESULTS: Tear meniscus values were significantly decreased in the aqueous tear-deficient dry eye group (p < 0.05). TMH, TMD, and TMA were positively correlated with Schirmer's test and tear break-up time (p < 0.05), and TMH and TMD were negatively correlated with corneal fluorescein staining in the aqueous tear-deficient dry eye group (p < 0.05). The AUROCs of TMH, TMD, and TMA were 0.978, 0.788, and 0.957, respectively. CONCLUSIONS: Tear meniscus values measured using FD-OCT were significantly lower in aqueous tear-deficient dry eyes and were correlated with Schirmer's test, tear break-up time, and corneal fluorescein staining. Tear meniscus measurements obtained using FD-OCT can be useful clinical parameters for the diagnosis and treatment of aqueous tear-deficient dry eye.

Key Words: Correlation;Dry eye;Optical coherence tomography;Tear meniscus