Analysis of Clinical Characteristics in Phlyctenular Keratoconjunctivitis at a Tertiary Center.

Jo, Dong Hyun; Kim, Mee Kum; Wee, Won Ryang; Lee, Jin Hak

doi:2011.52.1.7

J Korean Ophthalmol Soc > Volume 52(1); 2011 > Article

Original Article

Journal of the Korean Ophthalmological Society 2011;52(1):7-13.
DOI: https://doi.org/10.3341/jkos.2011.52.1.7 Published online January 15, 2011.

Analysis of Clinical Characteristics in Phlyctenular Keratoconjunctivitis at a Tertiary Center.

Dong Hyun Jo, Mee Kum Kim, Won Ryang Wee, Jin Hak Lee

¹Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. kmk9@snu.ac.kr
²Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea.
³Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea.

3차병원을 방문한 플릭텐각결막염 환자의 임상양상 분석

조동현^1,2ㆍ김미금^1,2ㆍ위원량^1,2ㆍ이진학^1,2,3

Department of Ophthalmology, Seoul National University College of Medicine¹, Seoul, Korea Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute², Seoul, Korea Department of Ophthalmology, Seoul National University Bundang Hospital³, Seongnam, Korea

Abstract

PURPOSE
To report the clinical characteristics of patients with phlyctenular keratoconjunctivitis at a tertiary care center in Korea. METHODS: The authors of the present study retrospectively reviewed the medical records of 26 patients who were diagnosed with phlyctenular keratoconjunctivitis, identifying the age and sex at diagnosis, diagnosis of the referring clinic, laterality and location of the lesions, the results of bacterial cultures from the meibum, and treatment options. RESULTS: Eighteen patients (76.2%) were female, and the mean age at diagnosis was 18.4 +/- 10.5 years. Nine patients (34.6%) showed evidence of bilateral diseases, and corneal lesions were observed in 27 eyes of 21 patients. Bacterial cultures from the meibum were performed for 17 patients, with the following results: 6 cases of Staphylococcus epidermidis, 4 cases of Corynebacterium species, and 1 case of Propionibacterium acne. Neovascularization with corneal phlyctenules occurred from the inferior quadrant mostly. Twenty-four patients received the remission treatment of prednisolone acetate 1% eye drops and evidence of regression of new vessels was observed in all patients. Three patients (16.7%) experienced recurrence despite the maintenance treatment of cyclosporine 0.05% eye drops. Visual acuities improved significantly after the remission treatment, as compared to the initial visit. CONCLUSIONS: The phlyctenular keratoconjunctivitis patients who visited the tertiary center in Korea showed similar findings regarding demographics, involvement of blepharitis, and identified microorganisms, as compared with patients in previous reports. However, corneal lesions involving the visual axis were frequent, suggesting that with proper diagnosis and treatment, improvement in visual acuities is possible.

Key Words: Blepharitis;Cornea;Keratoconjunctivitis;Korean;Phlyctenular keratitis