Presumed Intraocular Natural Killer/T-cell Lymphoma Combined with Nasal Lymphoma.

Jeong, Hoon Seok; Park, Sang Hui; Lee, Jae Hoon; Lee, Dae Yeong; Nam, Dong Heun

doi:2011.52.7.871

J Korean Ophthalmol Soc > Volume 52(7); 2011 > Article

Case Report

Journal of the Korean Ophthalmological Society 2011;52(7):871-875.
DOI: https://doi.org/10.3341/jkos.2011.52.7.871 Published online July 15, 2011.

Presumed Intraocular Natural Killer/T-cell Lymphoma Combined with Nasal Lymphoma.

Hoon Seok Jeong, Sang Hui Park, Jae Hoon Lee, Dae Yeong Lee, Dong Heun Nam

¹Department of Ophthalmology, Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea. eyedawns@gilhospital.com
²Department of Pathology, Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea.
³Department of Internal Medicine, Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea.

비강 림프종과 동반된 안구내 자연살해/T세포 림프종 추정 1예

정훈석¹⋅박상희²⋅이재훈³⋅이대영¹⋅남동흔¹

Departments of Ophthalmology¹, Patholog², Internal Medicine³, Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea

Abstract

PURPOSE
To report a case of presumed intraocular natural killer/T-cell lymphoma (NKTL). CASE SUMMARY: A 61-year-old male presented with visual disturbance of the left eye for duration of 3 years. He had been treated with systemic chemotherapy and radiotherapy for nasal NKTL 1 year prior. Inflammatory reaction in the anterior chamber and vitreous opacity were observed in the left eye. The patient was diagnosed with uveitis in the left eye at a local clinic 3 years prior to visiting us. Because the patient did not respond to anti-inflammatory therapy, we performed diagnostic and therapeutic vitrectomy. Intraoperatively, vitreous opacity was thin sheet like in appearance. The vitreous specimen contained few lymphoid cells and was positive for Epstein Barr virus-encoded RNA (EBER). Systemic workups showed no metastasis to other organs. The patient was treated with systemic methotrexate chemotherapy and intravitreal methotrexate injected 3 times (once per week). During the 12-month follow-up period after the last intravitreal injection, the recurrence of lymphoma and related uveitis was not observed.

Key Words: Diagnostic vitrectomy;Intraocular natural killer/T-cell lymphoma