| The Clinical Manifestations and Prognostic Factors of Autoimmune-Related Peripheral Corneal Ulcers. |
|
Dae Joong Ma, Hyuk Jin Choi, Mee Kum Kim, Won Ryang Wee |
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
2Laboratory of Corneal Regenerative Medicine and Ocular Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea. |
| 자가면역 연관 주변부각막궤양의 임상양상 및 예후인자 분석 |
|
마대중1⋅최혁진1,2⋅김미금1,2⋅위원량1,2 |
|
Department of Ophthalmology, Seoul National University College of Medicine1, Seoul, Korea Laboratory of Corneal Regenerative Medicine and Ocular Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute2, Seoul, Korea |
|
|
| Abstract |
PURPOSE
To investigate clinical manifestations and prognostic factors of autoimmune-related peripheral corneal ulcers. METHODS: Nineteen eyes in 18 patients who were diagnosed with autoimmune-related peripheral corneal ulcer from November 1999 to August 2010 were enrolled in the present study. Clinical manifestations and treatment results were investigated retrospectively. RESULTS: The average age at presentation was 64.6 years with female (66.7%) and unilateral (94.4%) dominance. The main etiologies were Mooren's ulcer (53.6%) and rheumatoid arthritis (26.3%). The ulcer depth was greater than 75% of the corneal thickness in more than half of the cases (57.9%) and the mean extent of the ulcer was 69.5degrees. There were no significant improvements in visual acuity after treatment (p = 0.789) and no significant differences in treatment outcomes among etiologies or treatment modalities. The patients who underwent ulcer recurrence (p = 0.048) or treatment failure (p = 0.005) had poorer final visual acuity than those patients who did not. The ulcer depth correlated with treatment failure (p = 0.037). The final visual acuity showed positive correlations with visual acuity at presentation (p = 0.031) and negative correlations with the number of recurrences (p = 0.042). CONCLUSIONS: The visual acuity at presentation and ulcer depths were significant prognostic factors. These factors appeared to be helpful in the treatment of marginal keratitis depending on the depth of the ulcer. |
| Key Words:
Autoimmune;Connective tissue disease;Mooren's ulcer;Peripheral corneal ulcer;Recurrence;Treatment failure |
|
PDF Links
Full text via DOI
Download Citation
