Clinical Features and Treatment Results of Conjunctival Lymphoproliferative Lesions.

Lim, Dae Won; Im, Seong Kyu; Yoon, Kyung Chul

Original Article

Journal of the Korean Ophthalmological Society 2004;45(11):1820-1826.
Published online November 1, 2004.

Clinical Features and Treatment Results of Conjunctival Lymphoproliferative Lesions.

Dae Won Lim, Seong Kyu Im, Kyung Chul Yoon

Department of Ophthalmology Chonnam National University Medical School and Hospital, Gwang-Ju, Korea. kcyoon@chonnam.ac.kr

결막에 발생한 림프구증식성 질환의 임상양상 및 치료결과

임대원 ( Dae Won Lim ) , 임성규 ( Seong Kyu Im ) , 윤경철 ( Kyung Chul Yoon )

Abstract

PURPOSE
To investigate the clinical features of conjunctival lymphoproliferative lesions and associated systemic lymphoma, and to determine the recurrence rate and prognosis according to treatment methods. METHODS: Eighteen patients with conjunctival lymphoproliferative lesions were followed up. We retrospectively analyzed data for clinical symptoms, anatomical location, histological type, associated systemic lymphoma, and treatment results. RESULTS: Conjunctival lymphoproliferative lesions were classified according to WHO classification: benign lymphoid hyperplasia in 7 patients, MALT-lymphoma in 7, and small B lymphocytic lymphoma in 4. Systemic lymphoma existed in 2 patients (11.1%). Remission was not achieved in one patients treated by surgical excision and chemotherapy. Complete remission was achieved in 5 patients with conjunctival malignant lymphoma treated by surgical excision, radiotherapy and chemotherapy. CONCLUSIONS: We consider that aggressive treatment using radiotherapy, chemotherapy and surgical excision in conjunctival malignant lymphoma is needful to achieve complete remission and prevent recurrence.

Key Words: Conjunctival lymphoproliferative lesions;MALT-lymphoma;Recurrence