| The Relationship Between the Activity of Matrix Metalloproteinase in the Aqueous Humor and the Development of Primary Open Angle Glaucoma. |
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Chang Won Kee, Sung Su Son, Byung Heon Ahn |
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Department of Ophthalmology, Samsung Medical Center, College of Medicine, Sungkyunkwan University, Seoul, Korea. |
| 방수내 Matrix Metalloproteinase 활성도와 원발개방각녹내장 발생과의 관계 |
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기창원(Chang Won Kee),손성수(Sung Su Son),안병헌(Byung Heon Ahn) |
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| Abstract |
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To investigate whether the abnormal expression of matrix metalloproteinases(MMPs) in the aqueous humor may case the development of glaucoma, the activity of MMP in the aqueous humor of galucoma and cataract patients were measured and compared. Six primary open angle glaucoma(POAG), 2 chronic angle closureglaucoma(CACG), 2 normal tension glaucoma(NTG), and 14 cataract patients were enrolled. Aqueous humor of each patients were collected during surgery, and total protein concentration and activity of gelatinase A in the aqueous humor were measured by protein assay kit and zymography, respectively. Total protein concentration and gelatinase A activity of POAG patients were increased by 2.1 times and 3.9 times, respectively compared to those of cataract patients. However, there were no statistically significant changes in total protein concentration and gelatinase A activity of CACG and NTG patients compared to those of cataract patients. In conclusion, the development of POAG may be associated with the abnormal expression of MMP in the aqueous humor. |
| Key Words:
Aqueous humor;CACG;MMPs;NTG;POAG |
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