| The Effects of Mitomycin C and Ascorbic Acid on the Holmium Laser Sclerostomy in Rabbits. |
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Sung Soo Kim, Young Joo Choe, Young Jae Hong |
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Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea. |
| 가토에서 시행된 흘미움레이저 공막절술에 대한 마이토마이신과 아스코빈산의 효과 |
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홍영재(Young Jae Hong),김성수(Sung Soo Kim),최영주(Young Joo Choe) |
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| Abstract |
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Several methods of mitomycin administration or subconjunctival injection of ascorbic acid was combined with holmium laser scleorstomy for the evaluation of their effects in the sclerostomy. Thirty rabbits(60 eyes) were divided into 6 groups. Group 1 received topical application of 0.04% mitomycin for 2 weeks ostoperatively. Group 2 received subconjunctival injection of 0.04% mitomycin 3 hours before sclerostomy combined with postoperative topical use of mitomycin. Group 3 received subconjunctival injection of 0.04% mitomycin just before operation. Suconjunctival injection of 0.004% mitomycin was underwent 3 hours before surgery in group 4 and just before scierostomy in group 5. After subconjuctival injection of 25mg ascorbic acid, sclerotomy was performed on group 6. We evaluated duration of success and complication, mean duration of success was 7.4 days, in group 1, 35 days in group 2, 11.9 days in group 3, 7.2 day in group 4, 10.1 days in group 5, and 10.7 days in group 6. All methods were less effective than Subconjunctival mitomycin injection 3 hours before surgery. Corneal erosion, corneal, opacity, hyphema, and early hypotony were found in mitomycin use. Ascorbic acid injection did not develop complications. In these results, the subconjunctival injection of 0.04% mitomycin C 3 hours before the holmium laser sclerostomy was regarded as the most effective to holmium laser sclerostomy without complications. Subconjunctival injection of ascorbic acid was helpful for sclerostomy but less effective than mitomycin use. |
| Key Words:
Ascorbic acid;Glaucoma filtering surgery;Holmium laser;Mitomycin;Sclerostomy |
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