| The Effect of Intracameral Triamcinolone Acetonide Injection on the Cornea in Rabbits. |
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Joo Youn Park, Hoon Dong Kim, Kyung Seek Choi |
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Department of Ophthalmology, Soonchunhyang University College of Medicine, Seoul, Korea. ckseek@naver.com |
| 가토안에서 전방내 트리암시놀론 주입술이 각막에 미치는 영향 |
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박주연ㆍ김훈동ㆍ최경식 |
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Department of Ophthalmology, Soonchunhyang University College of Medicine, Seoul, Korea |
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| Abstract |
PURPOSE
To evaluate the safety and effects of intracameral triamcinolone acetonide injection in rabbit corneas. METHODS: Triamcinolone acetonide in the amounts of 0.5, 1, and 2 mg was injected into the anterior chamber of rabbit eyes, and intraocular pressure, corneal thickness, and endothelial cell counts were evaluated on days 1, 3, 7, 14, and 28. Twenty-eight days after triamcinolone acetonide injection, the eyes were enucleated and examined after TUNEL staining. RESULTS: No statistically significant differences were found among control, 0.5, and 1 mg triamcinolone-injected eyes in central corneal thickness, endothelial cell density, pleomorphism, and polymegathism. There was no difference between 2 mg triamcinolone-injected eyes and control eyes for corneal thickness and cell density, but there were statistically significant differences between these two groups for pleomorphism (p<0.05) and polymegathism (p<0.05). CONCLUSIONS: The results of this study suggested that intracameral injections of 0.5~1 mg of triamcinolone acetonide are beneficial and cause no toxic effects on corneas. |
| Key Words:
Cornea;Intracameral triamcinolone acetonide injection |
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