| Concentration in the Cornea After Topical Administration of 1% Clotrimazole in Rabbits. |
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Soo Hwan Choi, Young Ho Hahn, Kwan Hyuk Kim |
1Department of Ophthalmology, Kosin Medical College, Korea.
2Department of Microbiology, Kosin Medical College, Korea. |
| 1% Clotrimazole 점안후 가토각막내 농도에 관한 연구 |
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최수환(Soo Hwan Choi),한영호(Young Ho Hahn),김광혁(Kwan Hyuk Kim) |
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| Abstract |
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The concentration of clotrimazole in the cornea considering the lapse of time after topical administration of 1% clotrimazole, in a single drop or 13 drops at an interval of 5 minutes, was evaluated by agar diffusion bioassay, The rabbits were divided into 3 groups: normal cornea, deepithelized cornea and Aspergillus keratitis, In the case of a single dose, the drug concentration in the normal cornea was lower than the value which can be measured, and the concentration in deeptithelized cornea was significantly higher than in keratitis(p<0.05). In the case of multiple doses, the drug concentration in keratitis was higher than in the deepitheHzed cornea and both of these were higher than in the norma cornea. EspeciaUy the group of keratitis had a significantly higher level(p<0.05) and an abrupt decrease of the drug concentration than the group of deepithelized cornea. This result means that the cornea during inflammation has increased permeability and great metabolic activity. In general the drug concentration in all groups except a single dose in the normal cornea was higher than minimal inhibitory concentration of clotrimazole against A. fumigatus, and this result suggests that the topical administration of 196 dotrimazole is likely to be efficacious in the treatment of Aspergillus keratitis. |
| Key Words:
Agar diffusion Bioassay;Aspergillus keratitis;Clotrimazole;Deepithelized cornea |
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