| Concentrations of Ofloxacin, Levofloxacin and Ciprofloxacin in Human Aqueous Humor after Topical Administration. |
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Yong Soo Han, Dong Heun Nam, Kyung Hwan Shyn, Ji Young Park, Kyoung Ah Kim, Sun Wook Kim, Jong Suk Song |
1Department of Ophthalmology, Gachon Medical School, Gil Medical Center, Incheon, Korea.
2Department of Pharmacology, Gachon Medical School, Gil Medical Center, Incheon, Korea.
3Balgun Eye Center, Korea Universtiy College of Medicine, Seoul, Korea.
4Department of Ophthalmology, Korea Universtiy College of Medicine, Seoul, Korea. crisim@freechal.com |
| 오플록사신, 레보플록사신 및 씨프로플록사신 점안 후 방수 내 농도 비교 |
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한용수1,남동흔1,신경환1,박지영2,김경아2,김선욱3,송종석4 |
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Department of Ophthalmology1 & Pharmacology,2 Gachon Medical School, Gil Medical Center, Incheon, Balgun Eye Center,3 Department of Ophthalmology, Korea Universtiy College of Medicine,4 Seoul, Korea |
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Correspondence:
Yong-Soo Han, M.D.1 |
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| Abstract |
PURPOSE
To evaluate the concentrations of commercially available ofloxacin 0.3%, levofloxacin 0.5%, and ciprofloxacin 0.3% topical ophthalmic solutions in human aqueous humor. METHODS: Patients scheduled to undergo phacoemulsification and posterior chamber lens insertion for treatment of cataract were enrolled in this prospective study. After informed consent was obtained, patients were randomized to receive 1 drop of ofloxacin 0.3%, levofloxacin 0.5%, or ciprofloxacin 0.3% topical ophthalmic solution 5 times at 1-hour intervals from 6pm one day before surgery and 3 further times at 5-min intervals immediately before surgery. After aspirating approximately 0.1 mL of aqueous fluid by paracentesis, surgery was commenced. We recorded the interval between the last drop and paracentesis. Specimens were stored at -70 degrees C until assayed by high-performance liquid chromatography. RESULTS: Thirty-four patients were enrolled. 14 male and 19 patients female. The mean age was 59.4 years. The mean concentrations of levofloxacin, ofloxacin and ciprofloxacin in aqueous humor were 577.8 ng/ml, 279.6 ng/ml and 53.0 ng/ml, respectively. The differences of concentration among the three groups were statistically significant. CONCLUSIONS: The concentration of levofloxacin 0.5% solution was highest, followed in order by ofloxacin 0.3% and ciprofloxacin 0.3%. |
| Key Words:
Concentration;Ciprofloxacin;Levofloxacin;Ofloxacin |
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