The Effect of 5-FU(5-fluorouracil) in the Filtering Surgery.

Lee, Jong Ho; Yoon, Hee Seong; Rho, Sae Heun

Original Article

Journal of the Korean Ophthalmological Society 1993;34(10):1044-1049.
Published online October 1, 1993.

The Effect of 5-FU(5-fluorouracil) in the Filtering Surgery.

Jong Ho Lee, Hee Seong Yoon, Sae Heun Rho

Department of Ophthalmology, Dong-A University, College of Medicine Pusan, Korea.

누공수술에 있어서 5-FU ( 5 - fluorouracil ) 의 치료효과

이종호(Jong Ho Lee),윤희성(Hee Seong Yoon),노세현(Sae Heun Rho)

Abstract

An antimetabolite, 5-fluorouracil(5-FU) has a property of inhibiting fibroblast proliferahon and is known to increase success rate of glaucoma filtering surgery in patients at risk by preventing postoperative scarring of a filtering bleb. Thirteen eyes of 13 patients with uncontrolled glaucoma at high risk for failures of standard filteration underwent trabeculectomy with post-operative 5-FU subconjunctival injections. The mean follow-up time was 7.3 months. The intraocular pressure was controlled in 77% of the over-all study patients after 1 month, 69% after 2 months and 54% after 6months, respectively. In patients with neovascular glaucoma, the intraocular pressure was controlled in 80% of the patients after 1 month and 60% after 2 months and 40% after 6 months. A corneal epithelial defect was the most common complicatio. No other severe complications were observed.

Key Words: 5-Fluorouracil;risky glaucoma;trabeculectomy