Extracellular Matrix in Human Trabecular Meshwork.

Park, Il Won; Ko, Myung Kyoo; Choe, Joon Kiu

Case Report

Journal of the Korean Ophthalmological Society 1990;31(3):297-301.
Published online March 1, 1990.

Extracellular Matrix in Human Trabecular Meshwork.

Il Won Park, Myung Kyoo Ko, Joon Kiu Choe

Department of Ophthalmology, School of Medicine, Hanyang University, Seoul, Korea.

정상안구 섬유주에서의 세포외기질의 분포

최준규(Joon Kiu Choe),박일원(Il Won Park),고명규(Myung Kyoo Ko)

Abstract

This study was performed to evaluate the distribution of extracellular matrix in the normal human trabecular meshwork. The trabecular meshworks obtained from 5 enucleated eyes due to traumatic eye-ball rupture were frozen processed, stained with monoclonal antibodies for fibronectin and type IV collagen, and observed by fluorescent microscopy. The indirect immunofluorescent study showed strong positive reactions in the subendothelial basement membrane for fibronectin and type IV collagen and negative reaction in the central core of trabecular beam. These results suggest that fibronectin and type IV collagen distribute predominantly in the basement membrane of the trabecular beam.

Key Words: extracellular matrix;fibronectin;trabecular meshwork;type IV collagen