Ultra-Structural Changes of the Chorioretina Following Intra-Vitreal Injection of Ornithine in Rabbit.

Kim, Byung Joo; Yoo, Yong Seok; Yoo, Jin Hyung

Original Article

Journal of the Korean Ophthalmological Society 1991;32(10):878-883.
Published online October 1, 1991.

Ultra-Structural Changes of the Chorioretina Following Intra-Vitreal Injection of Ornithine in Rabbit.

Byung Joo Kim, Yong Seok Yoo, Jin Hyung Yoo

¹Department of Ophthalmology, Inje University, College of Medicine, Seoul, Korea.
²Department of Ophthalmology, Wallace Memorial Baptist Hospital, Busan, Korea.

가토 초자체내 Ornithine 주입에 의한 망막과 맥락막의 미세구조의 변화

김병주(Byung Joo Kim),유용석(Yong Seok Yoo),유진형(Jin Hyung Yoo)

Abstract

The ultrastructural changes of the chorioretina following the intravitreal injection of ornithine in rabbit eyes at 1,2,4,8 week time intervals were investigated employing electron microscopy in this animal experiment. 1. 1 week after injection, swelling of the mitochondria in the cytoplasm of the pigment epithelium was seen. 2. 2 weeks after injection, phagosomes and phagolysosomes were present in the cytoplasm of the pigment epithelium and nerve elements in the inner nuclear layer disappeared and were replaced by Muller cell. 3. 4 weeks after injection, stroma of the choroid was atrophied and abundant melanocytes were aggregated, and papillary formed pigment epithelium with detachment of the retina was seen. 4. 8 weeks after injection, stromal atrophy and attenuated choriocapillaries of the choroid were present, and proliferation of the microvilli of the pigment epithelium after detachment of the retina was seen. 5. In summary intravitreal injection of ornithine in rabbits initially caused marked changes in the pigment epithelium with subsequent degeneration of the choroid and sensory retina.

Key Words: Chorioretina;Electron microscopy;Ornithine