| Inhibitory Effect of Topical Nonsteroidal Anti-inflammatory Agents to Prostaglandin before and after Anterior Chamber Paracentesis in Rabbits. |
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Ho Keol Lee, Jae Chan Kim, Kyung Hwan Shyn |
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Department of Ophthalmology, School of Medicine, Chung-Ang University, Seoul, Korea. |
| 가토 전방천자 전후의 비스테로이드성 소염점안제의 Prostaglandin 억제 효과 |
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이호걸(Ho Keol Lee),김재찬(Jae Chan Kim),신경환(Kyung Hwan Shyn) |
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| Abstract |
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It is known that inflammatory processes result from intraocular surgery or ocular trauma mediated by prostaglandin, which cause the protein amounts to increase in anterior chmaber, congestion of vessels, miosis and intraocular pressure to increase. In order to compare the anti-inflammatory effects of antiprostaglandin agents such as Aspegic(R), Profenal(R) and Ocufen(R) in 40 eyes of 20 rabbits, we measured the pupil diameter and amounts of PG E2 and total protein before and after paracentesis. The inhibitory effects of Aspegiz(R), Profenal(R) and Ocufen(R) to pupillary constnztion were significantly greater (p<0.05) than control. The lowering effect to PG E2 and total protein were greater in Aspegic(R), Profenal(R) and Ocufen(R) than control. Through over experiment we suggested that the topical non-steroidal anti-inflammatory agents such as Aspegic(R), Profenal(R), and Ocufen(R) can inhibit the PG activator in antivator chamber and interrupt the miosis and rising intraocular pressure during surgery. |
| Key Words:
Aspegic(R);Ocufen(R);Profenal(R);Prostaglandin;Inhibit |
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