| Dry Eye Syndrome and Morphological Changes of Meibomian Glands in Type 2 Diabetic Patients. |
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Ji Yoon Kwak, Kyu Ryong Choi, Kyung Eun Han, Roo Min Jun |
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Department of Ophthalmology, Ewha Womans University College of Medicine, Seoul, Korea. jrmoph@ewha.ac.kr |
| 제 2형 당뇨환자들의 건성안증후군과 마이봄샘의 형태학적 변화 |
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곽지윤 · 최규룡 · 한경은 · 전루민 |
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이화여자대학교 의과대학 안과학교실 |
Correspondence:
Roo Min Jun,
Email: jrmoph@ewha.ac.kr
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Received: 2 May 2019 • Revised: 30 May 2019 • Accepted: 23 October 2019 |
| Abstract |
PURPOSE
To evaluate the morphological changes of meibomian glands and dry eye syndrome in patients with type II diabetes. METHODS: The medical records of 72 diabetic patients referred to the ophthalmology clinic for the evaluation of diabetic retinopathy, who had dry eye symptoms, were retrospectively reviewed. RESULTS: A total of 72 patients, with an age of 56.3 ± 13.3 years, were analyzed. The group with diabetic retinopathy (52 patients) had a significantly lower tear film break-up time (p = 0.046), lower Schirmer's test value (p = 0.005), and higher percentage of upper (p = 0.036) and lower (p = 0.017) meibomian gland area losses than the group without diabetic retinopathy (20 patients). According to multilinear regression analyses considering sex, age, and diabetes-related characteristics, the Schirmer's test value was significantly lower with increasing stage of diabetic retinopathy (β = −1.180, p = 0.016). The percentage of upper meibomian gland area loss was significantly increased with increasing age (β = 0.605, p < 0.001), glycosylated hemoglobin (β = 1.881, p = 0.011), and stage of diabetic retinopathy (β = 4.458, p = 0.001). The percentage of lower meibomian gland loss area was significantly increased with increasing age (β = 0.443, p = 0.001) and stage of diabetic retinopathy (β = 4.879, p = 0.001). CONCLUSIONS: In patients with type 2 diabetes, the more severe the diabetic retinopathy, the more likely the meibomian gland loss will occur, so careful and appropriate treatment should be conducted. |
| Key Words:
Diabetic retinopathy;Dry eye syndrome;Meibomian gland |
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