J Korean Ophthalmol Soc > Volume 57(1); 2016 > Article
Journal of the Korean Ophthalmological Society 2016;57(1):71-79.
DOI: https://doi.org/10.3341/jkos.2016.57.1.71    Published online January 15, 2016.
Intravitreal Anti-Vascular Endothelial Growth Factor for Retinal Pigment Epithelial Tear in Retinal Angiomatous Proliferation.
Hyun Ji Hwang, Young Suk Chang, Jong Woo Kim, Tae Gon Lee, Chul Gu Kim, Sung Won Cho, Dong Won Lee, Jung Il Han, Jae Hui Kim
1Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea. kjh7997@daum.net
2Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Korea.
망막혈관종성증식에 동반된 망막색소상피파열에서 항혈관내피세포성장인자 주입술의 임상결과
건양대학교 의과대학 김안과병원 안과학교실1, 건양대학교 의과대학 안과학교실2
To evaluate the treatment outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) therapy for retinal pigment epithelial (RPE) tear in retinal angiomatous proliferation (RAP). METHODS: In the present study we retrospectively analyzed the medical records of 14 patients (14 eyes) diagnosed with RPE tear secondary to RAP treated with intravitreal anti-VEGF. Best-corrected visual acuity (BCVA) when the RPE tear developed was compared with BCVA at 6 months and at the final follow-up. RESULTS: The mean age of the study patients was 75.1 +/- 7.0 years and the mean follow-up period was 23.7 +/- 13.7 months. During the follow-up period, patients were treated with a mean of 2.8 +/- 1.3 intravitreal anti-VEGF injections. The mean logarithm of minimal angle of resolution BCVA when the RPE tear developed, at 6 months and at the final follow-up was 1.25 +/- 0.44, 1.44 +/- 0.56, and 1.65 +/- 0.39, respectively. The BCVA at 6 months was not different from the baseline value (p = 0.258), whereas the BCVA at the final follow-up was significantly worse than the baseline value (p = 0.002). CONCLUSIONS: The prognosis of RPE tear in RAP is poor despite anti-VEGF therapy. This result suggests further investigations regarding the prevention of RPE tear or more effective treatment method for this condition are necessary.
Key Words: Age-related macular degeneration;Anti-vascular endothelial growth factor;Retinal angiomatous proliferation;Retinal pigment epithelial tear

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