Comparison of Dorzolamide-Timolol Fixed Combination and Latanoprost, Effects on Intraocular Pressure and Ocular Pulse Amplitude.

Jang, Se Ran; Lee, Mar Vin; Ahn, Jae Hong

doi:2014.55.6.854

J Korean Ophthalmol Soc > Volume 55(6); 2014 > Article

Original Article

Journal of the Korean Ophthalmological Society 2014;55(6):854-859.
DOI: https://doi.org/10.3341/jkos.2014.55.6.854 Published online June 15, 2014.

Comparison of Dorzolamide-Timolol Fixed Combination and Latanoprost, Effects on Intraocular Pressure and Ocular Pulse Amplitude.

Se Ran Jang, Mar Vin Lee, Jae Hong Ahn

¹Department of Ophthalmology, Ajou University Medical Center, Ajou University School of Medicine, Suwon, Korea. chrisahn@ajou.ac.kr
²Department of Ophthalmology, DMC BunDang Jesaeng General Hospital, Seongnam, Korea.

도졸라미드-티몰롤 복합제제와 라타노프로스트 점안 전후의 안압과 안구박동크기 변화의 비교

장세란¹⋅이마빈²⋅안재홍¹

Department of Ophthalmology, Ewha Womans University School of Medicine¹, Seoul, Korea
Ewha Womans University Global Top ⁵ Research Program², Seoul, Korea

Abstract

PURPOSE
To compare dorzolamide-timolol fixed combination (DTFC) and latanoprost with regard to their effects on intraocular pressure (IOP) and ocular pulse amplitude (OPA). METHODS: Sixty eyes of 60 patients with open angle glaucoma or glaucoma suspect were included in the present study. Patients were divided into 2 groups, DTFC-treated (n = 30) and latanoprost-treated (n = 30). IOP and OPA were measured with dynamic contour tonometer (DCT) and Goldmann applanation tonometer (GAT), before and at least 1 month after treatment. RESULTS: GAT IOP, DCT IOP and OPA decreased by 2.25 +/- 2.23 mm Hg, 1.97 +/- 2.06 mm Hg, and 0.14 +/- 0.88 mm Hg, respectively in the DTFC-treated group. In the latanoprost-treated group, GAT IOP, DCT IOP and OPA was reduced by 2.74 +/- 2.96 mm Hg, 2.06 +/- 3.50 mm Hg, and 0.69 +/- 1.07 mm Hg, respectively. There was no significant difference (p = 0.311) in the decline of IOP between the 2 groups, but OPA of the DTFC-treated group decreased less than the latanoprost-treated group (p = 0.032). CONCLUSIONS: No significant differences were observed in the short-term decline of IOP between the 2 medications. However, the influence of DTFC on OPA appeared negligible in the latanoprost-treated group.

Key Words: Dorzolamide-timolol fixed combination;Dynamic contour tonometer;Intraocular pressure;Latanoprost;Ocular pulse amplitude