| Comparison of Retinal Nerve Fiber Layer Thickness Measured by Spectral-Domain and Time-Domain Optical Coherence Tomography. |
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Juhyang Lee, In Seok Song, Yu Jeong Kim, Yong Jae Cha, Ki Bang Uhm |
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Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Korea. KBUhm@hanyang.ac.kr |
| 스펙트럼영역과 시간영역 빛간섭단층촬영기로 측정한 망막신경섬유층 두께 비교 |
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이주향⋅송인석⋅김유정⋅차용재⋅엄기방 |
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Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Korea |
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| Abstract |
PURPOSE
To compare retinal nerve fiber layer (RNFL) thickness measured by time domain (Stratus) and spectral domain (3D) optical coherence tomography (OCT). METHODS: Sixty-nine normal subjects and 92 glaucoma patients were included in the present study. Peripapillary RNFL thickness was measured with Stratus fast RNFL scan and 3D optic disc cube scan on the same day. The relationship between RNFL thickness measurements of the two OCTs were evaluated using a Pearson's correlation analysis. A Bland-Altman plot was used for the comparison of Stratus-OCT and 3D-OCT. RESULTS: In all subjects, average, superior, and inferior quadrant RNFL thicknesses measured by Stratus-OCT were thicker than those measured by 3D-OCT. In contrast, temporal and nasal quadrant RNFL thicknesses measured by 3D-OCT were thicker than those measured by Stratus-OCT. Although there were absolute value differences in RNFL thicknesses, high correlation was observed between Stratus-OCT and 3D-OCT (average: r = 0.897, temporal quadrant: r = 0.728, superior quadrant: r = 0.811, nasal quadrant: r = 0.678, and inferior quadrant: r = 0.905). Bland-Altman plots showed that Stratus-OCT values were greater than 3D-OCT values with relatively high RNFL thickness and the opposite with low RNFL thickness. CONCLUSIONS: For thicker RNFL, Stratus-OCT measurements tend to be greater than 3D-OCT, while for thinner RNFL, 3D-OCT measurements tend to be greater than Stratus-OCT. This difference must be taken into account if comparing measurements made with a Stratus-OCT to the measurements of a 3D-OCT. |
| Key Words:
Glaucoma;Retinal nerve fiber layer;Spectral domain optical coherence tomography |
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