| Visual Function Test for Early Detection of Ethambutol-Induced Ocular Toxicity. |
|
Jae Keun Chung, Yong Beom Park, Sung Pyo Park |
1Department of Ophthalmology, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. sungpyo@hananet.net
2Department of Pulmonary and Critical Care Medicine, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. |
| 에탐부톨 안독성의 조기진단을 위한 시기능 검사의 연구 |
|
정재근1⋅박용범2⋅박성표1 |
Departments of Ophthalmology1, Pulmonary and Critical Care Medicine2, Hallym University Kangdong Sacred Heart Hospital,
Hallym University College of Medicine, Seoul, Korea |
|
|
| Abstract |
PURPOSE
The purpose of the present study was to investigate various visual function tests for early detection of ethambutol-induced ocular toxicity. METHODS: A prospective study of 20 eyes of 10 patients being treated with ethambutol was conducted. Visual acuity, visual field, color vision, fundus examination, contrast sensitivity, optical coherence tomography (OCT), and pattern-visual evoked potential (VEP) were assessed. Examinations were performed prior to therapy and every month for 5 months after treatment. VEP was performed every other month. The mean values of each parameter at each month were compared with the baseline examination and a p-value of <0.05 was considered significant. In addition, a greater than 2 standard deviation (SD) change in each parameter from the mean values at baseline was considered as an ocular toxicity induced change in each individual eye. RESULTS: On OCT, a significant increase of the average retinal nerve fiber layer thickness was detected after 4 months of therapy. VEP showed an increased mean latency of the P100 wave after 2 and 4 months of therapy. However, a greater than 2 SD change from the mean values of the baseline was not observed on OCT, while 30% (6/20) of the eyes showed more than a 2 SD increase in VEP latency. Visual acuity, color vision, fundus, contrast sensitivity, and visual field were not affected in any patients. CONCLUSIONS: The authors of the present study consider VEP as a sensitive test to detect early toxicity of ethambutol. VEP can be helpful in identifying subclinical ocular toxicity, especially in the high-risk patients. |
| Key Words:
Early detection;Ethambutol;Ocular toxicity;Visual evoked potential |
|
PDF Links
Full text via DOI
Download Citation
