J Korean Ophthalmol Soc > Volume 50(3); 2009 > Article
Journal of the Korean Ophthalmological Society 2009;50(3):365-375.
DOI: https://doi.org/10.3341/jkos.2009.50.3.365    Published online March 15, 2009.
The Efficacy of Photodynamic Therapy With Verteporfin for Polypoidal Choroidal Vasculopathy: Retrospective Multi-Center Case Study.
Jae Pil Shin, Hyoung Jun Koh, Oh Woong Kwon, Si Yeol Kim, Ha Kyoung Kim, Dong Heun Nam, Woo Ho Nam, Kyu Hyung Park, Boo Sup Oum, Jae Ryung Oh, Seung Young Yu, Ill Han Yoon, Hee Sung Yoon, Sung Chul Lee, Eun Goo Lee, Jae Heung Lee, Jeong Hee Lee, In Young Chung, Hee Seung Chin, Kuhl Huh, Hyung Woo Kwak
1Department of Ophthalmology, Kyungpook National University, College of Medicine, Daegu, Korea.
2Department of Ophthalmology, Yonsei University, College of Medicine, Seoul, Korea.
3Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University, College of Medicine, Seoul, Korea.
4Department of Ophthalmology, Gachon University of Medicine and Science, Gil Medical Center, Incheon, Korea.
5Department of Ophthalmology, Seoul National University, College of Medicine, Seoul, Korea.
6Department of Ophthalmology, Pusan National University, College of Medicine, Pusan, Korea.
7Department of Ophthalmology, Korea University, College of Medicine, Seoul, Korea.
8Department of Ophthalmology, Kyunghee University, College of Medicine, Seoul, Korea. hwkwak@khmc.or.kr
9Department of Ophthalmology, Inje University, College of Medicine, Pusan, Korea.
10Sungmo Eye Hospital, Pusan, Korea.
11Kong Eye Center, Seoul, Korea.
12Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Seoul, Korea.
13Department of Ophthalmology, Ewha Womans University, College of Medicine, Seoul, Korea.
14Department of Ophthalmology, Gyeongsang National University, College of Medicine, Chinju, Korea.
15Department of Ophthalmology, Inha University, College of Medicine, Incheon, Korea.
결절맥락막혈관병증에서 광역학치료의 효과에 대한 다기관 연구
신재필1ㆍ고형준2ㆍ권오웅2ㆍ김시열1ㆍ김하경3ㆍ남동흔4ㆍ남우호3ㆍ박규형5ㆍ엄부섭6ㆍ오재령7ㆍ유승영8ㆍ윤일한9ㆍ윤희성10ㆍ이성철2ㆍ이은구11ㆍ이재흥12ㆍ이정희13ㆍ정인영14ㆍ진희승15ㆍ허 걸7ㆍ곽형우8
Department of Ophthalmology, Kyungpook National University, College of Medicine1, Daegu, Korea / Department of Ophthalmology, Yonsei University, College of Medicine2, Seoul, Korea / Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University, College of Medicine3, Seoul, Korea / Department of Ophthalmology, Gachon University of Medicine and Science, Gil Medical Center4, Incheon, Korea / Department of Ophthalmology, Seoul National University, College of Medicine5, Seoul, Korea / Department of Ophthalmology, Pusan National University, College of Medicine6, Pusan, Korea / Department of Ophthalmology, Korea University, College of Medicine7, Seoul, Korea / Department of Ophthalmology, Kyunghee University, College of Medicine8, Seoul, Korea / Department of Ophthalmology, Inje University, College of Medicine9, Pusan, Korea / Sungmo Eye Hospital10, Pusan, Korea / Kong Eye Center11, Seoul, Korea / Department of Ophthalmology, Konyang University, Kim’s Eye Hospital12, Seoul, Korea, / Department of Ophthalmology, Ewha Womans University, College of Medicine13, Seoul, Korea / Department of Ophthalmology, Gyeongsang National University, College of Medicine14, Chinju, Korea / Department of Ophthalmology, Inha University, College of Medicine15, Incheon, Koera
Abstract
PURPOSE
To evaluate the efficacy of photodynamic therapy (PDT) with verteporfin for polypoidal choroidal vasculopathy (PCV) in Korean patients. METHODS: Clinical data of patients who were treated with PDT for PCV and followed up for more than 6 months were collected from 14 hospitals around the country. The changes in the best corrected visual acuity, angiographic outcome, retinal thickness measured by optical coherence tomography (OCT), and adverse effects of treatment were evaluated. RESULTS: Eighty six patients (86 eyes) were recruited (male: 75.6%, age: 65.9+/-8.3 years, mean follow-up: 14.8+/-10.2 months). The mean logMAR visual acuity at baseline was 0.55+/-0.32 and did not show any statistically significant difference from the final mean logMAR visual acuity (0.53+/-0.54) (p=0.639). The mean treatment session number of PDT was 2+/-1.2. Visual acuity stabilized or improved in 70.9% of patients. Visual acuity improved by more than 2 lines in 33 eyes (38.4%) and worsened by more than 2 lines in 21 eyes (24.4%) of patients. Vascular leakage decreased in 62.5% of patients in fluorescein angiography and polypoidal lesions disappeared or were reduced in 57.3% of patients in indocyanine green angiography. There was no systemic adverse effect of PDT, but increased subretinal hemorrhage after PDT occurred in 10 eyes (11.6%). CONCLUSIONS: In polypoidal choroidal vasculopathy, photodynamic therapy with verteporfin is safe and effective for preserving visual acuity and reducing vascular leakage and retinal thickness.
Key Words: Photodynamic therapy;Polypoidal choroidal vasculopathy;Verteporfin


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