| Glaucoma Filtering Surgery With Low Concentration of Cyclosporin A in Rabbits: A Pilot Study. |
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Yeon Deok Kim, Hyung Bin Hwang, Myoung Hee Park, Jung Il Moon |
1Glaucoma and Cataract Services, HanGil Eye Hospital, Incheon, Korea.
2Department of Ophthalmology, Visual Science, St. Mary's Hospital, The Catholic University of Korea School of Medical, Seoul, Korea. jimoon@catholic.ac.kr |
| 토끼에서 녹내장 여과수술 후 저농도 사이클로스포린이 창상치유에 미치는 영향 |
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김연덕1,2ㆍ황형빈2ㆍ박명희2ㆍ문정일2 |
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Glaucoma and Cataract Services, HanGil Eye Hospital1, Incheon, Korea Department of Ophthalmology, Visual Science, St. Mary’s Hospital, The Catholic University of Korea School of Medical2, Seoul, Korea |
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| Abstract |
PURPOSE
The effect of 0.2% cyclosporin A (CsA) as an adjuvant therapy after glaucoma-filtering surgery was the focus of this study. METHODS: A posterior lip sclerotomy was performed in 16 eyes of 8 rabbits, and 0.2% CsA was administered into the right eyes. The left eyes served as controls. The intraocular pressure (IOP) was measured 1, 3, 5, 7, 14, and 28 days after surgery. Hematoxylin-eosin (HE) and anti-bromodeoxyuridine (BrdU) immunocytochemical staining were performed at 1, 2, 4, and 8 weeks. RESULTS: The IOP at 7 and 14 days after surgery was lower in the 0.2% CsA group and statistically significant (P=0.047, P=0.48; respectively). HE staining did not show any difference between experimental and control eyes, but anti-BrdU staining showed a lower number of positive cells in the experimental eyes at 1 week. The fibroblast proliferation rate was significantly lower 1 week after surgery in the 0.2% CsA group (P=0.003). CONCLUSIONS: An effect of 0.2% CsA on early wound healing was observed. The data suggest that a low concentration of CsA can be useful when employed as adjuvant therapy in glaucoma filtering surgery. |
| Key Words:
Adjuvant therapy;Antifibrotic agent;Cyclosporin;Glaucoma filtering surgery;Wound healing |
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