Changes of Tear Parameters after Using Cyclosporine A in Dry Eye with Thyroid Ophthalmopahty.

Oh, Han Jin; You, In Cheon; Yoon, Kyung Chul

Original Article

Journal of the Korean Ophthalmological Society 2007;48(5):630-636.
Published online May 31, 2007.

Changes of Tear Parameters after Using Cyclosporine A in Dry Eye with Thyroid Ophthalmopahty.

Han Jin Oh, In Cheon You, Kyung Chul Yoon

Department of Ophthalmology, Chonnam National University Medical School & Hospital, Gwangju, Korea. kcyoon@chonnam.ac.kr

건성안이 동반된 갑상샘안병증 환자에서 사이클로스포린 A 점안액 사용 후 눈물막과 안구표면의 변화

오한진,유인천,윤경철

Department of Ophthalmology, Chonnam National University Medical School & Hospital, Gwangju, Korea

Correspondence: Han Jin Oh, M.D.

Abstract

PURPOSE
This study was performed to evaluate the changes of tear film and ocular surface after using cyclosporine A in patients with thyroid-associated ophthalmopathy accompanied by dry eye. METHODS: Corneal sensitivity test (CST), tear break-up time (BUT), basal tear secretion test (BST), fluorescein staining (FS), tear clearance rate (TCR), and conjunctival impression cytology were evaluated in 28eyes of 28 patients with thyroid-associated ophthalmopathy accompanied by dry eye before and after using 0.1 cyclosporine A. RESULTS: CST (P=0.03), BUT (P<0.01), and BST (P=0.01) were shown significant improvements after 3 month treatment with topical 0.1% cyclosporine A. There are also shown improvments of impression cytologic findings, reduction of the degree of conjunctival squamous cell metaplasia (P=0.02) and increment of the density of goblet cell (P=0.04) after 3 month treatment. But TCR and FS were shown no significant changes after treatment. CONCLUSIONS: The improvement of parameters of tear films and ocular surface suggest the treatment with 0.1% cyclosporine A for dry eye in thyroid ophthalmopathy was effective.

Key Words: Cyclosporine A;Ocular surface;Tear film;Thyroid-associated ophthalmopathy