| Discriminating Ability of Scanning Laser Polarimetry with Variable Corneal Compensation in Normal and Glaucomatous Eyes. |
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Jong Uk Hwang, Ji Yong Jung, Hyun Soo Cho, Michael Scott Kook |
1Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. mskook@amc.seoul.kr
2Department of Ophthalmology, Soonchunhyang University, College of Medicine, Seoul, Korea. |
| 한국인에서 각막보정주사레이저편광측정계의 진단적 유용성 |
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황종욱1,정지용2,조현수1,국문석1 |
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Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center1, Seoul, Korea Department of Ophthalmology, Soonchunhyang University, College of Medicine2, Seoul, Korea |
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Correspondence:
Jong Uk Hwang, M.D.1 |
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| Abstract |
PURPOSE
We investigated the diagnostic ability of scanning laser polarimetry with variable corneal compensation (GDx VCC) parameters to distinguish glaucomatous eyes with different degrees of visual field abnormality from normal eyes. METHODS: Subjects were divided into a control group (n=47) and an early to moderate glaucoma group (n=100). The latter included 53 early glaucoma patients (mean deviation > -6dB with a Humphrey Field Analyzer). Using a receiver operating characteristic (ROC) curve, the diagnostic power of GDx VCC parameters was analyzed and the correlations between those parameters and Humphrey Field Analyzer (HFA) indices were statistically analyzed. RESULTS: Nerve fiber indicator (NFI) provided the best discriminating ability with the highest area under the ROC curve (AUROC) value for detecting eyes with early to moderate perimetric glaucoma. TSNIT average showed the highest AUROC value for detecting eyes with early perimetric glaucoma. The optimal NFI cut-off value to discriminate between the control group and early to moderate group was 22, offering the best combination of sensitivity (88.0%) and specificity (83.0%). The optimal TSNIT average cut-off value to discriminate between the control group and early glaucoma group was 53.49 micrometer, providing the best combination of sensitivity (84.9%) and specificity (85.1%). Most of the thickness parameters showed higher AUROC values than those of the ratio or modulation parameters. A statistically significant correlation was found between the GDx VCC parameters and HFA indices. CONCLUSIONS: Measurement of the retinal nerve fiber layer (RNFL) by scanning laser polarimetry with variable corneal compensation is useful in discriminating between normal and glaucomatous eyes. |
| Key Words:
Anterior segment birefringence;Early detection of glaucoma;Early glaucoma;Scanning laser polarimetry;Variable corneal compensation |
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