| Tear Film and Ocular Surface Changes after Umbilical Cord Serum Therapy in Dry Eye Syndrome. |
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Kyung Chul Yoon, Seong Kyu Im, Yeoung Geol Park, Jin Choi |
1Department of Ophthalmology, Chonnam University Medical School and Hospital, Gwang-Ju, Korea. kcyoon@chonnam.ac.kr
2Department of Obstetrics and Gynecology, Eun Hospital, Gwang-ju, Korea. |
| 안구건조증 환자에서 제대혈청 점안액 치료 후 눈물막 및 안구표면의 변화 |
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윤경철1,임성규1,박영걸1,최진2 |
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Department of Ophthalmology, Chonnam University Medical School & Hospital1, Gwang-Ju, Korea Department of Obstetrics and Gynecology, Eun Hospital2, Gwang-ju, Korea |
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Correspondence:
Kyung-Chul Yoon, M.D.1 |
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| Abstract |
PURPOSE
To evaluate the changes of tear film and ocular surface after umbilical cord serum therapy in patients with severe dry eye syndrome. METHODS: Forty-one eyes of 25 patients with severe dry eye syndrome were treated with umbilical cord serum eyedrops. Before and after treatment, symptom score, tear film break-up time (BUT), Schirmer test, corneal sensitivity, keratoepitheliopathy score, and impression cytology were performed. RESULTS: Before treatment, symptom score, BUT, Schirmer test, corneal sensitivity, and keratoepitheliopathy score were 3.18 +/- 0.50, 3.50 +/- 1.27 sec, 3.24 +/- 0.94 mm, 51.63 +/- 9.29 mm, and 6.13 +/- 2.85, respectively. Two months after treatment, the respective parameters were 1.03 +/- 0.53 (P<0.001), 5.42 +/- 2.79 sec (P<0.001), 3.42 +/- 1.16 mm (P=0.067), 52.87 +/- 7.92 mm (0.071), and 2.10 +/- 1.98 (P<0.001). In impression cytology, the grade of squamous metaplasia and goblet cell density were 2.44 +/- 0.71 and 75.05 +/- 41.81 cells/mm2 before treatment, and 1.47 +/- 0.62 and 165.48 +/- 39.19 cells/mm2 at 2 months after treatment, respectively (P<0.001). CONCLUSIONS: Umbilical cord serum treatment is clinically applicable and effective in patients with severe dry eye syndrome. |
| Key Words:
Dry eye syndrome;Impression cytology;Umbilical cord serum |
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