The Complications Developed after Repeated Botulinum Toxin Injection.

Im, Chan Young; Han, Seung Han; Lee, Jong Bok

Original Article

Journal of the Korean Ophthalmological Society 2002;43(12):2489-2493.
Published online December 1, 2002.

The Complications Developed after Repeated Botulinum Toxin Injection.

Chan Young Im, Seung Han Han, Jong Bok Lee

Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. Shhan222@yumc.yonsei.ac.kr

반복적인 보툴리눔 독소 화학절단술 시행 후 발생한 합병증의 고찰

임찬영 ( Chan Young Im ) , 한승한 ( Seung Han Han ) , 이종복 ( Jong Bok Lee )

Abstract

PURPOSE
To investigate the incidence of complication associated with repeated botulinum toxin chemodenervation in extraocular muscle. METHODS: 47 patients who had taken botulinum toxin chemodenervation from 1996 to November 2001 were reviewed retrospectively. 10 patients had taken repeated injection. Saline diluted botulinum toxin was directly injected into the extraocular muscle through the Teflon coated needle. RESULTS: In 10 patients, 5 patients had complications which were 2 cases of hypertropia, 2 cases of ptosis and 1 case of retrobulbar hemorrhage who was 44 year old woman taken 5 times of botulinum toxin injection. She was successfully treated with lateral canthotomy and cantholysis. CONCLUSIONS: Rate of complication in repeated botulinum toxin chemodenervation was not different from that of single procedure. We experienced one case of retrobulbar hemorrhage in 10 patients with repeated botulinum injection.

Key Words: Botulinum toxin injection;Repeated injection;Retrobulbar hemorrhage