The Changes of Tear Flow and Tear Film Stability after Antiglaucoma Drug Instillation.

Yoon, Gil Joong; Kim, Dae Hyun

Original Article

Journal of the Korean Ophthalmological Society 2001;42(12):1666-1673.
Published online December 1, 2001.

The Changes of Tear Flow and Tear Film Stability after Antiglaucoma Drug Instillation.

Gil Joong Yoon, Dae Hyun Kim

Department of Ophthalmology, Chosun University Medical College, Korea. Yoonalpha@hanmail.net

항녹내장 약제 점안 후 눈물분비와 눈물막 안정성의 변화

윤길중(Gil Joong Yoon),김대현(Dae Hyun Kim)

Abstract

PURPOSE
To investigate the changes in tear flow and tear filim stability in patients with long-term instillation of antiglaucoma drug. METHODS AND OBJECTS: We measured Schirmer test score and tear film break-up time (BUT) in long-term antiglaucoma drug instilling 60 patients (120eyes) who had been diagnosed with open angle glaucoma and in randomly selected 60 normal subjects (120eyes) from March 2000 to February 2001 at Chosun University Hospital. Obtained results were retrospectively analyzed with the age progression and sex of subjects, duration of instillation, number and type of drugs to find out correlations between these factors. RESULTS: Average Schirmer test score and BUT were measured considerably lower in antiglaucomat drug instilled group compared to normal-subjects group (P<0.05, student t-test). Both measurements considerably decreased as age of patients and drug instillation time increased (P<0.05, ANOVA test). But number and type of instilled drugs had no considerable correlation to the obtained results (P>0.05, ANOVA test). CONCLUSIONS: It should be predicted that the patients who had instilled antiglaucoma drug for a long time and who are also of old age may develop dry eye syndrome and eye surface problem. So special care should be taken with glaucoma treatment in such cases.

Key Words: Antiglaucoma drug;BUT;Schirmer test