| A Comparision of Short Term use Effects and Satety of Timoptic(R) with those of Cosopt(R) in Normal Korean. |
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Jae Chol Shim, Chul Myong Choe, Gong Je Seong |
1Department of Ophthalmology, National Police Hospital, Seoul, Korea The institute of Vision Reseach, Korea.
2Department of Ophthalmology, Yonsei University College of Medicine Yongdong Severance Hospital, Korea.gjseong@yumc.yunsei.ac.kr |
| 정상인에서 단기간 사용한 Timoptic(R)과 Cosopt(R)의 효과 및 부작용 비교 |
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심재철 ( Jae Chol Shim ) , 최철명 ( Chul Myong Choe ) , 성공제 ( Gong Je Seong ) |
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| Abstract |
PURPOSE
This study is to compare the clinical effects and safety of 0.5% timolol maleate and 2% dorzolamide hydrochloride combinationis (Cosopt(R)) with those of 0.5% timolol maleate (Timoptic(R)) in normal Korean. METHODS: We instilled Timoptic(R) eye drops two time a day into one eye and Cosopt(R) eyedrops two times a day into the other eye for thirty days and measured the intraocular pressure (IOP) and side effects in normal Korean volunteers. RESULTS: Cosopt(R) was superior to Timoptic(R) in reducing IOP, but had more frequent side effects such as burning, blurred vision, tearing, ocular pain, injection than those of Timoptic(R). However side effects of Cosopt(R) were tolerable enough to refrain from discontinuation. CONCLUSIONS: Due to the greater IOP lowering efficacy of CosoptR compared to that of Timoptic(R), it can be used as an effective substitute in case of uncontrolled IOP with beta blockers alone. |
| Key Words:
Glaucoma;Intra ocular pressure;timolol;Dorzolamide;Combination |
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