| Endotoxin of Gram Positive Bacteria Induced Acute Uveitis in the Rat. |
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Jun Sik Kim, Bo Moon Shin, Myung Jin Joo |
1Department of Ophthalmology, Seoul Paik Hospital, Inje University College of Medicine, #85 Chu-dong-2-ga, Chung-ku, Seoul, 100-032, Korea.
2Department of Clinical Pathololgy, Seoul Paik Hospital, Inje University College of Medicine, Korea. |
| Rat 에서 발생한 그람 양성균 내독소에 의한 급성 포도막염 |
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김준식(Jun Sik Kim),신보문(Bo Moon Shin),주명진(Myung Jin Joo) |
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| Abstract |
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The purpose of this study is to examine the capacity of lipoteichoic acid (LTA) to induce intraocular inflammation in the rat. LTAs, obtained from Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus faecalis, were suspended in saline solution in 15 mg/kg concentration and injected into both footpads of female Lewis rats. Lipopolysaccharide (LPS) was injected in the same way. It has been known that LPS induced acute uveitis experimentally in the rat. The uveitis changes were assessed by protein concentration in the aqueous humor and pupil size after injection. Twenty four hours after administration, the protein concentration of LPS injected rats was 667.00+/-45.13 mg/dl, and those of LPA injected rats Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus faecalis were 167.67+/-17.75 mg/dl, 63.00+/-8.85 mg/dl, and 53.93+/- 13.76 mg/dl, respectively. Anterior uveitis induced by LTAs was weaker than that induced by LPS. This model may be useful for investigation of Gram-positive bacterial infection and uveitis. |
| Key Words:
Anterior uveitis;Lipopolysaccharide;Lipoteichic acid |
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