| The Relationship between Nitric Oxide and CAtaractohenesis after Eximer Laser Photorefractive Keratectomy. |
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Noh Young Bae, Ji Han Ryon, Kwang Jin Baek, Kyung Hwan Shyn, Jae Chan Kim |
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Bae Eye Clinic. |
| 엑시머레이저 각막절제술 후 백내장 유발과 Nitric Oxide와의 관계 |
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배노영(Noh Young Bae),류지환(Ji Han Ryon),백광진(Kwang Jin Baek),신경환(Kyung Hwan Shyn),김재찬(Jae Chan Kim) |
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| Abstract |
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To assess the change of nitric oxide(NO) concentration according to photorefractive keratectomy(PRK) depth and the role of NO in cataractohenesis after excimer laser PRK. The treated 36 rabbits were divided into 12 groups according to PRK depth(-3.0, -7.0, -11.0 diopter [0]), the dates of sampling(the 1st day and the 7th day after PRK), and reatment of NOS inhibitor (NG-nitro-L-arginine methylester, L-NAME). NO concentration and superoxide dismutase(SOD) activity in the aqueous humor and malondialdehyde(MDA) concentration in the lens were measured. Changes of lens epithelium were examined by eletron microscopy on the 3rd day and the 6th day after -11.0D of PRK. The NO and MDA concentration in the group without L-NAME treatment on the 1st day after -11.0D of PRK were significantly higher than those in the L-NAME treated group and control group. The activity of SOD increased in all of the PRK treated group on the 1st day and was even higher on the 7th day. The histopathological changes of lens epithelium on the 3rd day after PRK were compatible with cellular necrosis and those of the 6th day after PRK were compatible with cellular reparing. The results suggested that the toxicity of NO after PRK correcting over -11.0D may a role in cataractogenesis, but the progress could be suppressed by treatment of NOS inhibitor. |
| Key Words:
Excimer laser PRK;Malondialdehyde;Nitric oxide;Superoxide dismutase |
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