The Effects of 2% Dorzolamide(Trusopt) and 0.12% UF-021(Rescula)on Intraocular Pressure and Peripapillary Retinal and Optic Nerve Head Microcirculation .

Woo, Jin Ho; Park, Woo Chan; Rho, Sae Heun

Original Article

Journal of the Korean Ophthalmological Society 1999;40(3):772-778.
Published online March 1, 1999.

The Effects of 2% Dorzolamide(Trusopt) and 0.12% UF-021(Rescula)on Intraocular Pressure and Peripapillary Retinal and Optic Nerve Head Microcirculation .

Jin Ho Woo, Woo Chan Park, Sae Heun Rho

Department of Ophthalmology, College of Medicine, Dong-A University.

정상안에서 2% Dorzolamide(Trusoptⓡ)와 0.12% UF-021(Rescula)이 안압과 유두주위망막과 시신경유두의 미세순환에 미치는 영향

우진호(Jin Ho Woo),박우찬(Woo Chan Park),노세현(Sea Heun Rho)

Abstract

We investigated the effect of 2% dorzolamide and 0.12% UF-021 on intraocular pressure and peripapillary and optic nerve head microcirclation with Heidelberg Retina Flowmeter. The 40 eyes of 40 normal subjects were divided 2 groups. 2% Borzolamide and 0.12% UF-021 were instilled in each group. The IOP and microcirculation of peripillary retina and optic nerve head were measured before and 90min, 4, 8, 12, 24 hours after instillation. The IOP was decreased at 90 minutes, 4, 8 hours after instillation of 2% dorzolamide and maximal reduction of IOP was observed at 90 minutes (P<0.05). The IOP was decreased at 90min, 4, 8, 12 hours after instillation of 0.12% UF-021 and maximal reduction of IOP was observed at 4 hours(P<0.05). But, there was no statistically significant changes of microciculation in both groups(P>0.05). We suggest that 2% dorzolamide and 0.12% UF-021 reduce the IOP, but do not alter the mictocirculation of peripapillary retina and optic nerve head.

Key Words: Dorzolamide;Heidelberg Retina Flowmeter;Intraocular pres-sure;Retinal and optic nerve head microcirculation;UF 021