The Therapeutic Effect of Levocabastine Eye Drops on Allergic Conjunctivitis: A Multicenter Study.

Kim, Hyo Myung; Kang, Shin Jeong; Kim, Ki San; Kim, Man Soo; Kim, Jae Deok; Kim, Jae Chan; Myung, Yoon Won; Park, Yeoung Gcol; Park, Woo Chan; Shin, Jong Chul; Woo, Kyung In; Lee, Jong Soo; Lee, Jong Hyuck; Leen, Chang Yeun; Lee, Ila Bum; Wee, Won Ryang; Chung, Sung Kun; Chung, Jang Ilyun; Jin, Kyung Hyun; Choi, Si Hwan; Hong, Sung Bum; Hong, Sung Pyo

Original Article

Journal of the Korean Ophthalmological Society 1997;38(12):2120-2128.
Published online December 1, 1997.

The Therapeutic Effect of Levocabastine Eye Drops on Allergic Conjunctivitis: A Multicenter Study.

Hyo Myung Kim, Shin Jeong Kang, Ki San Kim, Man Soo Kim, Jae Deok Kim, Jae Chan Kim, Yoon Won Myung, Yeoung Gcol Park, Woo Chan Park, Jong Chul Shin, Kyung In Woo, Jong Soo Lee, Jong Hyuck Lee, Chang Yeun Leen, Ila Bum Lee, Won Ryang Wee, Sung Kun Chung, Jang Ilyun Chung, Kyung Hyun Jin, Si Hwan Choi, Sung Bum Hong, Sung Pyo Hong

알레르기결막염에 대한 레보카바스틴 점안액의 치료 효과 - 다기관 연구 -

김효명(Hyo Myung Kim),강신정(Shin Jeong Kang),김기산(Ki San Kim),김만수(Man Soo Kim),김재덕(Jae Deok kim),김재찬(Jae Chan Kim),명윤원(Yoon Won Myoung),박영걸(Yeoung Geol Park),박우찬(Woo Chan Park),신정철(Jong Chul Shin),우경인(Kyung In Woo),이종수(Jong Soo Lee),이종혁(Jong Hyuck Lee),이창연(Chan

Abstract

The efficacy nd tolerance of topical administration of levocabastine(0.5mg/ml)were evaluated in patients with allergic conjunctivitis. A total of 166 patients who had a typical history of atopy and a positive skin test were recruited in this study. Five clinicl symptoms(itch, tearing, chemosis, lid edema and conjunctival injection) were assessed according to a four point scale before the treatment and at 1 and 2 weeks post-therapy. Total symptom severity score before the therapy, 6.68, was remarkably decreased to 2.86 at 1 week and 2.08 at 2 weeks after the treatment. The investigators rated the treatment as globally good or excellent in 68.1% of patients checked at 1 week and 72.5% at 2 weejs after treatment. And the patients evaluated that the therapy ws good to excellent in 66.9% at 1 week and 73.1% at 2 weeks after treatment. Levocabastine eye drops has a fast onet of action with 55.4% of the patients feeling symptom relief within 15 minutes after the first administration. The adverse effect was experienced in 44 patients. Ocular irritation sign, such as foreign body sensation or soreness, was the most frequently reported complaint. These results suggest that levocabastine eye drops is an effective and safe topical alternative for treatment of allergic conjunctivitis.

Key Words: Allergic conjunctivitis;Levocabastine;Skin test;Topical