Observation of Damage to the Blood-Aqueous Barrier after Trabeculectomy with Mitomycin C.

Chung, Hak Sung; Lee, Young Ghee; Park, Hae Song; Houng, Young Jae

Original Article

Journal of the Korean Ophthalmological Society 1997;38(12):2177-2181.
Published online December 1, 1997.

Observation of Damage to the Blood-Aqueous Barrier after Trabeculectomy with Mitomycin C.

Hak Sung Chung, Young Ghee Lee, Hae Song Park, Young Jae Houng

¹The Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
²Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.

Mitomycin C 를 병용한 섬유주절제술 후 혈액방수장벽의 손상관찰

정학성(Hak Sung Chung),이영기(Young Ghee Lee),박혜성(Hye Sung Park),홍영재(Young Jae Houng)

Abstract

We observed the breakdown of the blood-aqueous barrier after trabeculectomy with mitomycin C by using laser flaremeter. There were 20 patients (25 eyes) of which 9 patients(11 eyes) were applied 0.02% MMC for 3minutes during the trabeculectomy and 11 patients (14 eyes) were not applied MMC. All patients were diagnosed as primary open angle glaucoma and underwent trabeculectomy. The preoperative, postoperative 1 day and 3 months aqueous flare intensity were 10.8+/- 5.05, 15.6+/- 5.32, 10.1+/- 4.55(photon count/msec)in group with MMC and 10.6+/-4.04,15.9+/-3.30, 9.2+/-3.94(photon count/msec) in group without MMC Anterior chamber flares were highest on the first postoperative day, declining rapidly in the first week with more gradual recovery to preoperative level by 1 month postoperatively, which shows the breakdown of blood-aqueous barrier by surgery. There was no statistically significant difference between the two groups in postsurgical aqueous flare intensity. 0.02% MMC does not appear.

Key Words: Mitomycin C;Trabeculectomy;Blood aqueous barrier;Laser flaremeter