Experimental Retianl Vein Occlusion in Albino Rats.

Ham, Don Il; Kim, Seong Jun; Park, Seok Joon; Chang, Kwang; Chung, Hum

Original Article

Journal of the Korean Ophthalmological Society 1998;39(3):530-538.
Published online March 1, 1998.

Experimental Retianl Vein Occlusion in Albino Rats.

Don Il Ham, Seong Jun Kim, Seok Joon Park, Kwang Chang, Hum Chung

¹Department of Ophthalmology, College of Medicine, Sung Kyun Kwan University, Seoul, Korea.
²Department of Ophthalmology, College of Medicine, Seoul National University.

흰쥐에서의 실험적 망막정맥폐쇄

함돈일(Don Il Ham),김성준(Seong Jun Kim),박석준(Seok Joon Park),장 광(Kwang Chang),정 흠(Hum Chung)

Abstract

The retinal vein occlusion is one of the most common, vision-threatening retinal diseases, and the establishment of animal model in rats will be of great help for further study. We occluded retinal veins with rose bengal dye injection followed by argon green laser photocoagulation in albino rats and confirmed the occlusion of veins with fluorescein angiography one hour after photocoagulation. We occluded half of an all of major retinal veins in 12 eyes, respectively. After 1-2 weeks of follow-up, histologic examinations were done. Eyes which underwent occlusion of all major retinal veins showed severe retinal atrophy and preretinal neovas-cularization developed in two eyes. Eyes which underwent occlusion of half of retinal veins showed relatively less damage and the number of retinal ganglion cells was significantly reduced in occluded area than that in control area (P=0.0033), which might represent the ischemic damage of inner retina. We expect that it will be possible to establish an animal model of retinal vein occlusion in albino rats using this method.

Key Words: Retinal vein occlusion;Animal model;Rose bengal;Laser photocoagulation