| Additive effect of Dapiprazole and Pilocarpine for the Reversal of Mydriasis and Cycloplegia. |
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Young Mi Choi, Jung Hyub Oh |
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Department of Ophthalmology, Seoul Adventist Hospital, Seoul, Korea. |
| Dapiprazole 과 pilocarpine 의 조절마비 회복의 보강효과 |
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최영미(Young Mi Choi),오중협(Jung Hyub Oh) |
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| Abstract |
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We assessed the combined effects of dapiprazole, an alpha-adrenergic receptor blocker, with pilocarpine. direct-acting parasympathomimetics, on reversing mydriasis and cycloplegia in 40 eyes (20 subjects) who received 1% tropicamide or 2.5% phenylephrine for pupillary dilation and cycloplegic refraction. These results were compared to 40 eyes (20 subjects) that received dapiprazole alone. The study was divided into four groups, each of which consisted of 20 eyes that received either 1% tropicamide or 0.5% phenylephrine followed by instillation of 0.5% dapiprazole alone or in combination with 2% pilocarpine. A significant difference in the reduction of pupil size and the increase in accommodative amplitude has been observed between the groups that received dapiprazole alone and those received both dapiprazole and pilocarpine(p<0.001). These results suggest that dapiprazole and pilocarpine eyedrops have additive effects on reversing both mydriasis and cycloplegia after instillation of 1% tropicamide or 2.5% phenylephrine for pupillary dilation and cycloplegic refraction. |
| Key Words:
Cycloplegia;Dapiprazole;Mydriasis;Pilocarpine |
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