Effect of Fibrin Glue(Tissel(R))in Experimental Corneal Perforation.

Chung, Eui Hong; Yoo, Jin Hyung; Lim, In Sook; Lee, Song Hee

Original Article

Journal of the Korean Ophthalmological Society 1990;31(6):711-723.
Published online June 1, 1990.

Effect of Fibrin Glue(Tissel(R))in Experimental Corneal Perforation.

Eui Hong Chung, Jin Hyung Yoo, In Sook Lim, Song Hee Lee

¹Department of Ophthalmology, Pusan Paik Foundation Hospital, Inje University, School of Medicine, Korea.
²Department of Ophthalmology, Seoul Paik Foundation Hospital, Inje University, School of Medicine, Korea.
³Department of Pathology, Pusan Paik Foundation Hospital, Inje University, School of Medicine, Korea.
⁴Lee Song Hee eye clinic, Korea.

각막천공상에 대한 Fibrin Glue ( Tisseel(R) ) 의 창상치유에 관한 실험적 연구

정의홍(Eui Hong Chung),유진형(Jin Hyung Yoo),임인숙(In Sook Lim),이송희(Song Hee Lee)

Abstract

Fibrinogen is converted into fibrin by the action of thrombin under presence of calcium. In addition to its hemostatic effect, fibrin coagulum has tissue adhesive effect and fibroblast stimulating effect in the healing process. Perforating wounds about 1mm X 3mm in size were made in the center of rabbit corneas, and then were treated with fibrin glue. Simple full-thickness lacerations were also made in the central cornea of the other eye without any treatment as a control group. These eyes were enucleated after various periods of interval and the wound sites were studied with light and electron microscope. Tissue defect of perforated cornea was closed well by fibrin glue and active proliferation of the fibroblasts was seen near the glue. From these results, fibrin glue may be useful in the treatment of human corneal perforation and it will be used for the other ocular surgery.

Key Words: Perforated cornea;fibrin glue;fibroblast stimulating effect