Age-related Changes of the Cellularity and Acid Mucopolysaccharides in the Trabecular Meshwork of the Normal Korean.

Uhm, Seung Lyong; Lee, Mee Young; Baek, Nam Ho

Original Article

Journal of the Korean Ophthalmological Society 1991;32(6):467-475.
Published online June 1, 1991.

Age-related Changes of the Cellularity and Acid Mucopolysaccharides in the Trabecular Meshwork of the Normal Korean.

Seung Lyong Uhm, Mee Young Lee, Nam Ho Baek

Department of Ophthalmology, Catholic University Medical College, Seoul, Korea.

정상 한국인에서 연령에 따른 섬유주 세포 충실성 및 Acid mucopolysaccharides 의 변화

엄승룡(Seung Lyong Uhm),백남호(Nam Ho Baek),이미영(Mee Young Lee)

Abstract

We evaluated thirty normal human eyes(aged from 22 to 95) to investigate the changes with age of the cellularity and acid mucopolysaccharides in the trabecular meshwork. The cellularities were evaluated from the number of the cells per unit area of trabecular meshwork and the number of cells per unit length of trabecular meshwork. In addition, acid mucopolysaccharides(AMS) were investigated by counter staining the trabecular meshwork specimens, with Van Gieson following colloidal iron. The results were as follows: 1. With age, cellularities of the whole trabecular meshwork and the counterpart of filtration region decreased significantly(p0.05). 2. The trabecular meshwork cellularity and the absolute number of cells were decreased by 40.0% and 35.9%, respectively, for those aged from 22 to 95. 3. There was no strong relation between the change of acid mucopolysaccharides of the trabecular meshwork and aging process. The grade +1 AMS was observed in 15 eyes(50.0%) and was the most prevalent.

Key Words: Cellularity;Acid mucopolysaccharides;Glaucoma;Trabecular meshwork;Aging process