Retinal Toxicity of Repetitive Intravitreal Injections of Amphotericin B.

Lee, Byung Joon; Oum, Boo Sup

Original Article

Journal of the Korean Ophthalmological Society 1991;32(7):550-556.
Published online July 1, 1991.

Retinal Toxicity of Repetitive Intravitreal Injections of Amphotericin B.

Byung Joon Lee, Boo Sup Oum

Department of Ophthalmology, College of Medicine, Pusan National Univerity, Pusan, Korea.

초자체강내 Amphotericin B 의 반복 투여에 의한 망막의 조직학적 변화

이병준(Byung Joon Lee),엄부섭(Boo Sup Oum)

Abstract

Authors evaluated the retinal toxic reation of intravitreal injection with a regimens of 10 microgram of amphotericin B on both phakic and aphakic eyes of rabbits. In addition to the eye receiving single injection, the effects of repeating the same dose second and third time at interval of 1 week were examined by light microscopy after last injection. The results were as follows: 1. Even a single intravitreal injection with regimens of 10 microgram amphotericin B, vitreous opacities and posterior subcapsular lens opacities were observed ophthalmoscopically. 2. A single and repeated intravitreal injections with regimens of 10 microgram amphotericin B showed focal areas of retinal toxic reation. 3. Lens extraction did not modify the retinotoxic reation of intravitreally administrated amphotericin B. 4. Repetitive intravitreal injection of amphotericin B did not show increasing retinal toxic reation.

Key Words: Amphotericin B;Intravitreal injections;Retinal toxicity