The Role of Prostaglandins in Surgically Induced Miosis.

Lee, Kyoo Won; Lee, Sung Su

Original Article

Journal of the Korean Ophthalmological Society 1991;32(11):964-969.
Published online November 1, 1991.

The Role of Prostaglandins in Surgically Induced Miosis.

¹The First Eye Center, Daegu, Korea.
²Department of Ophthalmology, College of Medicine, Yeungnam University, Daegu, Korea.

수술로 인한 동공 수축에 있어서 Prostaglandins 의 역할

이규원(Kyoo Won Lee),이성수(Sung Su Lee)

Abstract

In cataract surgery, the surgically induced miosis complicate the removal of lens materials and implantation of a posterior chamber intraocular lens, which increase the risk of ocular trauma and its associated complication. The refore maintenance of mydriasis during cataract syrgery makes the operation easier and brings a good results. This study was performed in rabbit and human eyes to assess the role of the prostaglandins in surgically induced miosis by observing the reduction of pupillary constriction and by measuring the amount of prostaglandins in aqueous humor when the 1.0% suprofen, cyclo-oxygenase inhibitor, was used, and to assess the effect of suprofen in intraocular pressure. In the results, suprofen inhibits syrgically induced miosis (p value: <0.01, human <0.01) without intraocular pressure change, and for this miosis, prostaglans and for this miosis, prostaglandins are at least partially responsible.

Key Words: Cyclo-oxygenase inhibitor;Miosis;Prostaglandins;Suprofen