Effect of Topical Betoptic(R) and Mikelan(R) on the Perfusion Pressure.

Yoo, Kyung Won; Whang, Chang Jin; Lee, Jong Ho; Rho, Sae Heun

Randomized Controlled Trial

Journal of the Korean Ophthalmological Society 1992;33(9):901-906.
Published online September 1, 1992.

Effect of Topical Betoptic(R) and Mikelan(R) on the Perfusion Pressure.

Kyung Won Yoo, Chang Jin Whang, Jong Ho Lee, Sae Heun Rho

¹Department of Ophthalmology, College of Medicine, Dong-A University, Pusan, Korea.
²Department of Ophthalmology, College of Medicine, Busan National University, Pusan, Korea.

2% Betoptic(R) 과 0.5% Mikelan(R) 이 시신경관류압에 미치는 영향

유경원(Kyung Won Yoo),황창진(Chang Jin Whang),이종호(Jong Ho Lee),노세현(Sae Heun Rho)

Abstract

The effects of topical Betoptic(R) 0.5% and Mikelan(R) 2% on the ophthalmic artery blood pressure and perfusion pressure were investigated in 30 healthy subjects using ophthalmodynamometer and Goldmann applanation tonometer. The subjects were divided into two groups and each has 15 healthy subjects. In a randomized, double-blind study, one eye of each subject received one drop of Betoptic(R) 0.5% or Mikelan(R) 2%, and fellow eye was received a drop of placebo. Diastolic ophthalmic artery blood pressure (OABPd), systolic artery blood pressure (OPBPs), and intraocular pressure (lOP) were measured just before and 2 hours after the instillation of the drugs. Mean ophthalmic arery blood pressure (OABPm) was calculated as OABPm = OABPd + 1/3 (OABPs - OABPd) and the perfusion pressure (PP) was calculated as PP = OABPm - lOP. The perfusion pressure (pp) was Betoptic(R)-treated group was increased by 9%, and that of Mikelan(R)-treated group was increased by 13%, these increasement were statistically significant (Both group P<0.01).

Key Words: Betoptic(R) 0.5%;Mikelan(R) 2%;Ophthalmodynamometer;Perfusion