5-Fluorouracil in a Collagen Sponge and Glaucoma Filtering Surgery.

Kim, Dong Myung

Original Article

Journal of the Korean Ophthalmological Society 1988;29(5):901-907.
Published online May 1, 1988.

5-Fluorouracil in a Collagen Sponge and Glaucoma Filtering Surgery.

Dong Myung Kim

Depatrment of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.

녹내장누공수술과 5 - Fluorouracil in a Collagen Sponge

김동명(Dong Myung Kim)

Abstract

A histologic study was performed if fibroblast proliferation could be inhibited and filtering bleb longevity could be enhanced in rabbits by delivery of 5-fluorouracil(0.5 mg) in a collagen sponge implant. Results showed that fibroblast proliferation was inhibited and bleb longevity was prolonged when compared to controls. And it is theorized that if an antitumor agents can be delivered in small and sustained amounts after filtering agents can be delivered in small and sustained amounts after filtering surgery, this may enhance bleb longevity and unnecessary drug toxicity.