A Case Report of Intractable Scleritis Effectively Treated with Infliximab.

Kim, Dong Hyun; Wee, Won Ryng; Lee, Jin Hak; Kim, Mee Kum

doi:2008.49.10.1690

J Korean Ophthalmol Soc > Volume 49(10); 2008 > Article

Case Report

Journal of the Korean Ophthalmological Society 2008;49(10):1690-1695.
DOI: https://doi.org/10.3341/jkos.2008.49.10.1690 Published online October 15, 2008.

A Case Report of Intractable Scleritis Effectively Treated with Infliximab.

Dong Hyun Kim, Won Ryng Wee, Jin Hak Lee, Mee Kum Kim

¹Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. kmk9@snu.ac.kr
²Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea.
³Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea.

치료가 잘 되지 않는 공막염에서 인플릭시맙(infliximab)의 효과 1예 보고

김동현^1,2ㆍ위원량^1,2ㆍ이진학^1,3ㆍ김미금^1,2

Department of Ophthalmology, Seoul National University College of Medicine1, Seoul, Korea / Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute2, Seoul, Korea / Department of Ophthalmology, Seoul National University Bundang Hospital3, Seongnam, Korea

Abstract

PURPOSE
To report a case of a patient with intractable scleritis with conventional immunosuppressive therapy who showed effective treatment with infliximab. CASE SUMMARY: A 71-year-old man presented with orbital cellulitis and diffuse anterior scleritis of his left eye. Although orbital cellulites showed remission with topical and systemic antibiotics, scleritis persisted despite a combination therapy of immunosuppressive agents (cyclosporin, mycophenolate, prednisolone) for 1 month. Finally, he was given infliximab (5 mg/kg) intravenously three times at 2-week intervals, after which ocular pain, chemosis, conjunctival injection, and sclera thickening considerably reduced, and scleritis completely remitted. CONCLUSIONS: The administration of Infliximab seems to be an effective therapy in patients with intractable scleritis undergoing conventional therapy.

Key Words: Infliximab;Scleritis;TNF-a