| The Neuroprotective Effect of Intravitreal Melatonin Injection in Pressure-induced Retinal Ischemia. |
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Seung Joon Lee, Won Sub Son, Hyung Woo Kwak |
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Department of Ophthalmology, Kyung Hee University Hospital. |
| 실험적으로 유도된 가토의 허혈망막에서 Melatonin 의 신경보호효과 |
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이승준(Seung Joon Lee),손원섭(Won Sub Son),곽형우(Hyung Woo Kwak) |
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| Abstract |
PURPOSE
The authors sought to determine the neuroprotective effect of melatonin in a model of ischemic injury in rabbit retina. METHODS: Ischemia was induced by high intraocualr pressure. A dose of 100 microgram of melatonin or dimethyl sulfoxide(DMSO) alone was injected intravitreally just after the induction of ischemia. After 7 and 14 days, the neuroprotective effect of melatonin on ischemic retina was examined with light microscope and transmission electron microscope. RESULTS: The authors found reduction of cytoplasm of retinal ganglion cell(RGC), vacuole formation, chromatin condensation and rupture of nuclear membrane in ischemia-injured eyes treated with DMSO alone. But in melatonin treated eyes, we found that RGC layer's thickness and number of RGC reduced and destruction of cytoplasmic organells and nuclear damage were minimal. The partial recovery of wave is noted in melatonin-treated eyes after ischemia induction. CONCLUSIONS: The melatonin(100 microgram) protected the rabbit retina from high intraocular pressure-induced ischemic injury when administered intravitreally. Melatonin may be useful to decrease neuronal damage in the retina as a result of ischemic injury. But further investigations are neccesary to decide effective concentration, route and time of administration. |
| Key Words:
Ganglion cell;Melatonin;Retinal ischemia |
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