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Original Article
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J Korean Ophthalmol Soc. 2019;60(3):239-245. Published online March 15, 2019.
DOI: https://doi.org/10.3341/jkos.2019.60.3.239
- Comparison of Efficacy and Sensation of Instillation between 0.05% Cyclosporine Nanoemulsion and Microemulsion Type.
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Eun Hae Shin, Dong Hui Lim, Chan Min Yang, Tae Young Chung
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Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. taeyoung15.chung@samsung.com
Department of Preventive Medicine, Graduate School, The Catholic University of Korea, Seoul, Korea.
- 0.05% 사이클로스포린 마이크로에멀젼과 나노에멀젼에서 치료 후 건성안 지표 및 점안감 비교
- 신은혜<sup>1</sup>⋅임동희<sup>1,2</sup>⋅양찬민<sup>1</sup>⋅정태영<sup>1</sup>
- Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. taeyoung15.chung@samsung.com
Department of Preventive Medicine, Graduate School, The Catholic University of Korea, Seoul, Korea.
- Received: April 19, 2018; Revised: May 26, 2018 Accepted: February 19, 2019.
- Abstract
- PURPOSE
To evaluate and compare the efficacy and sensation of instillation between 0.05% cyclosporine nanoemulsion group and microemulsion group. METHODS: This is a double-blind, prospective randomized clinical trial. Patients had 2 weeks of wash-out period before the study. They were randomly assigned to either nanoemulsion group or microemulsion group and treated with each group's cyclosporine eye drop. Artificial eye drop and topical steroid were used together according to severity of dryness of cornea. We checked every patient's Break-up time (BUT), Schirmer test, Staining Score and Ocular surface disease index (OSDI) on baseline, 1 month and 3 months after. Patients also self-checked frequency of use of artificial eye drop and topical steroid. Sensation of instillation was also checked. RESULTS: Both nanoemulsion eye-drop and microemulsion eye-drop improved BUT, Schirmer test, Staining Score and OSDI throughout 12 weeks. The nanoemulsion type reduced OSDI significantly compared to the microemulsion type. The mean frequency of use of artificial tear and topical steroid was similar in both groups. Foreign body sense score was higher in microemulsion group. CONCLUSIONS: 0.05% cyclosporine nanoemulsion type has simillar efficacy and subjectively less foreign body sensation.
Keywords :Cyclosporine;Dry eye syndromes;Microemulsion;Nanoemulsion
