J Korean Ophthalmol Soc > Volume 59(12); 2018 > Article
Journal of the Korean Ophthalmological Society 2018;59(12):1166-1172.
DOI: https://doi.org/10.3341/jkos.2018.59.12.1166    Published online December 15, 2018.
Predictors of Success of Selective Laser Trabeculoplasty Adjusted for Intraocular Pressure Variations.
Jun Seok Lee, Chong Eun Lee, Sam Seo, Kyoo Won Lee
1Cheil Eye Hospital, Daegu, Korea. vit.s0324@gmail.com
2Department of Ophthalmology, Keimyung University School of Medicine, Daegu, Korea.
단안 선택적 레이저섬유주성형술에서 안압 변동을 보정한 성공예측인자의 분석
이준석1⋅이종은2⋅서샘1⋅이규원1
제일안과병원1, 계명대학교 의과대학 안과학교실2
Correspondence:  Sam Seo,
Email: vit.s0324@gmail.com
Received: 12 July 2018   • Revised: 23 August 2018   • Accepted: 23 November 2018
Abstract
PURPOSE
To investigate the efficacy, and identify predictors of success of selective laser trabeculoplasty (SLT) in open-angle glaucoma (OAG) patients after adjusting for intraocular pressure (IOP) changes in the untreated fellow eye. METHODS: This retrospective chart review included 52 eyes of 52 OAG patients who underwent SLT in one eye and were followed-up for at least 1 year after the procedure. The IOP was measured before the treatment, at 1, 2, and 3 months posttreatment, and every 3 months thereafter. To account for the possible influence of IOP fluctuations on laser outcomes, post-laser IOP values of the treated eye of each patient were also analyzed, after adjusting for IOP changes in the untreated fellow eye. Success was defined as an IOP decrease ≥20% of the pretreatment IOP. The success rate was determined based on Kaplan-Meier survival analysis and factors predictive of success were analyzed using the Cox proportional hazard model. RESULTS: The mean pretreatment IOP was 23.17 ± 6.96 mmHg. The mean IOP reduction was 5.59 ± 4.78 mmHg (29.7%) and the success rate was 65.4% at 1 year. The adjusted mean IOP reduction was 4.70 ± 4.67 mmHg (23.9%) and the adjusted success rate was 53.9%. Pretreatment IOP was associated with SLT success; the higher the pretreatment IOP, the greater the post-laser IOP reduction (p = 0.025). Age and mean deviation index did not show a significant association with SLT success (p = 0.066 and p = 0.464, respectively). CONCLUSIONS: SLT is a safe and effective alternative method of IOP reduction in OAG patients. Herein, pretreatment IOP was the only factor significantly associated with SLT success. IOP fluctuations of the untreated eye should be considered for a better understanding of the impact of treatment.
Key Words: Intraocular pressure;Open-angle glaucoma;Predictive factors;Selective laser trabeculoplasty;Success rate


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